血府逐瘀汤加味治疗慢性乙型肝炎肝纤维化（瘀血阻络证）的临床观察

发布时间：2018-02-15 11:23

  本文关键词： 血府逐瘀汤 肝纤维化 瘀血阻络证 临床观察　出处：《长春中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过与复方鳖甲软肝片的研究比较,观察血府逐瘀汤加味治疗慢性乙型肝炎肝纤维化(瘀血阻络证)的临床疗效。方法:将来自长春中医药大学附属医院肝脾胃病科门诊符合慢性乙型肝炎肝纤维化(瘀血阻络证)临床诊断的患者共72位,按1:1的比例采用随机对照方法,随机分为2组,治疗组36例,对照组36例。治疗组给予血府逐瘀汤加味(由桃仁,红花,川芎,大黄等药物组成),对照组给予复方鳖甲软肝片,两组疗程均为24周。观察并记录两组患者治疗前后中医症状积分、血清肝纤维化标志物(HA、LN、IV-C、PC-Ⅲ)及肝功能指标,进行统计学分析比较。结果:(1)中医证侯疗效评价,治疗组30例中,显效、有效分别为11例、16例,总有效率为90.00%;对照组30例中,显效、有效分别为5例,13例,总有效率为60.00%。治疗组和对照组总有效率比较~△P0.05。(2)经统计学比较,治疗前两组肝功能指标无明显差异,P0.05,具有可比性。治疗结束后两组肝功能指标均有改善,治疗组与本组治疗前比较*P0.05,治疗组改善更明显,与对照组治疗后比较▲P0.05,具有显著性差异。(3)经统计学比较,两组在治疗前肝纤维化指标无明显差异,P0.05,具有可比性。治疗结束后两组血清肝纤维化指标均有改善,治疗组与本组治疗前比较*P0.05,与对照组治疗后比较▲P0.05,具有显著性差异。(4)抗肝纤维化综合疗效比较,治疗组,显效7例,有效19例,总有效率86.67%,对照组,显效4例,有效13例,总有效率56.67%,治疗组与对照组总有效率比较~△P0.05,具有显著性差异。结论:由以上数据可得出,治疗组明显优于对照组。表明血府逐瘀汤加味治疗慢性乙型肝炎肝纤维化(瘀血阻络证)可明显改善患者胁痛、腹胀等症状,修复受损肝细胞,改善肝纤维化病变程度,提高患者生存质量,为日后临床科学、合理用药提供依据,进一步丰富了中医药理论治疗肝纤维化的内涵。
[Abstract]:Objective: to compare the results with compound Biejia Ruangan tablets. To observe the clinical effect of Xuefu Zhuyu decoction on chronic hepatitis B liver fibrosis (blood stasis obstruction of collaterals). Methods: the outpatient department of liver and spleen gastropathy, affiliated hospital of Changchun University of traditional Chinese Medicine, was in accordance with chronic hepatitis B liver fibrosis. There were 72 patients (blood stasis and obstruction of collaterals) clinically diagnosed. According to the ratio of 1: 1, randomly divided into two groups, 36 cases in the treatment group and 36 cases in the control group. The treatment group was given Xuefu Zhuyu decoction (composed of peach kernel, safflower, Chuanxiong, rhubarb, etc.) and the control group was given compound Biejia Ruanggan tablets. The course of treatment in both groups was 24 weeks. The scores of TCM symptoms, serum markers of hepatic fibrosis (HALNNX IV-C- 鈪，

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