中医辨证治疗慢性阻塞性肺疾病急性加重期的临床研究

发布时间：2018-02-25 15:12

本文关键词： 慢性阻塞性肺疾病急性加重期辨证论治临床疗效　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察中医辨证组方在治疗慢性阻塞性肺疾病急性加重期的临床疗效,与单用西药治疗进行比较,总结出具有中医药特色并具有疗效优势的治疗方案,从而拓展慢性阻塞性肺疾病急性加重期的治疗途径,增加治疗慢性阻塞性肺疾病急性加重期的方法。方法:采用队列研究方法,将260例符合慢性阻塞性肺疾病急性加重期诊断标准的住院患者为研究对象,将患者病例分为治疗组和对照组。其中对照组55例,给予西医常规治疗(吸氧、抗感染、止咳化痰、解痉平喘等)。治疗组205例,在予西医常规治疗的基础上,按照中医证型(表寒里热、痰热蕴肺、痰浊壅肺、肺脾两虚、肺肾两虚)给予中药口服,一日两次。观察治疗前后两组患者总住院天数、主要症状、次要症状、临床疗效等指标,整理数据资料,并进行统计学处理和分析。结果:根据病例数据统计结果示,两组比较,在住院时间方面,治疗组较对照组可缩短患者住院时间;在症状方面,在咳嗽、咳痰、胸闷、紫绀、口干、出汗等方面,治疗组的症状改善明显优于对照组(P0.05);在饮食方面,治疗组的改善情况优于对照组;在喘息、气短、哮鸣音方面,治疗组和对照组的症状改善情况类似,无显著差异。在实验室指标方面,两组在治疗前后均有改善,在白细胞计数、中性粒细胞百分比、C反应蛋白及血气分析PH、PaO2方面,两组比较无统计学差异(P0.05)。在疗效方面,治疗组总有效率高于对照组。结论:中医治疗慢性阻塞性肺疾病急性加重期疗效较单纯西药更佳,能改善患者临床症状,缩短其住院天数,从而改善患者的生存质量。本课题结果表明中医药治疗慢性阻塞性肺疾病急性加重期方面有一定优越性,值得临床参考和推广。
[Abstract]:Objective: to observe the clinical effect of TCM syndrome differentiation prescription in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). In order to expand the treatment of acute exacerbation of chronic obstructive pulmonary disease, increase the treatment of acute exacerbation of chronic obstructive pulmonary disease. 260 inpatients who met the diagnostic criteria for acute exacerbation of chronic obstructive pulmonary disease were divided into treatment group and control group. 55 cases in control group were treated with routine western medicine treatment (oxygen inhalation, anti-infection, cough and phlegm control). Treatment group 205 cases, on the basis of routine treatment of western medicine, according to the TCM syndrome type (epiphlegm heat, phlegm heat accumulation lung, phlegm turbid obstruction of lung, deficiency of lung and spleen, deficiency of lung and kidney), oral administration of Chinese medicine. In 1st, we observed the total hospitalization days, main symptoms, secondary symptoms, clinical efficacy and other indicators of the two groups before and after the treatment, collated the data, and conducted statistical analysis. Results: according to the statistical results of the case data, In comparison between the two groups, in terms of hospitalization time, the treatment group can shorten the hospitalization time of the patients compared with the control group; in terms of symptoms, such as cough, expectoration, chest tightness, cyanosis, dry mouth, sweating, and so on, The improvement of symptoms in the treatment group was significantly better than that in the control group (P 0.05); in the diet, the improvement in the treatment group was better than that in the control group; in terms of wheezing, shortness of breath and wheezing, the improvement of symptoms in the treatment group and the control group was similar. There was no significant difference in laboratory indexes between the two groups before and after treatment. There was no significant difference in white blood cell count, percentage of neutrophil C-reactive protein and blood gas analysis between the two groups (P 0.05). The total effective rate of the treatment group is higher than that of the control group. Conclusion: the curative effect of traditional Chinese medicine on acute exacerbation of chronic obstructive pulmonary disease is better than that of western medicine alone, which can improve the clinical symptoms of the patients and shorten their hospitalization days. So as to improve the quality of life of patients. The results show that TCM treatment of acute exacerbation of chronic obstructive pulmonary disease has some advantages, and is worthy of clinical reference and promotion.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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