养阴清咽饮防治放射性口腔干燥症的临床研究

发布时间：2018-03-08 06:44

本文选题：养阴清咽饮　切入点：放射性口腔干燥症　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：研究目的:旨在观察养阴清咽饮对放射性口干症患者的临床疗效,为中医药防治放射性口腔干燥症提供客观依据,进一步扩展中医药防治放疗毒副反应的内涵。研究方法:采用开放性随机对照试验研究方法,将59例病例采用随机数字表法为2组,治疗组29例,对照组30例,治疗组采用养阴清咽饮联合放疗治疗,对照组采用单纯放疗治疗,两组治疗过程中出现的严重不良反应均采取相同对症处理方式。比较两组病例放疗完成率、口干症出现的时间及累积放射剂量、口干程度分级、唾液流量、KPS、不良反应及安全性。采用SPSS 19.0统计学软件进行统计分析。结果:(1)本研究共纳入59例患者,其中治疗组29例,对照组30例,治疗过程中脱落和剔除的患者总共7人,最后纳入统计分析的患者为52例;最初对59例鼻咽癌患者的构成分析发现,两组患者的性别、年龄、临床分期、KPS评分等基本情况经统计学分析,P值均0.05,即上述各方面无明显差异,两组具有齐同可比性。(2)口干出现的时间及累计放射剂量:治疗组出现口干的时间晚于对照组,两组相比有显著性差异(P0.05);出现口干累计放射剂量两组相比有显著性差异(P0.05)。(3)口咽反应:口咽反应程度治疗组较对照组轻,两组比较具有显著性差异(P0.05)。(3)唾液流速:两组放疗前后组内比较均具有显著性差异(P0.01),说明放疗剂量越大,对唾液腺损伤越大,唾液流速越小;且放疗后两组唾液流速下降程度存在显著性差异(P0.05)。(4)口干程度分级:放疗后治疗组口干程度相比对照组明显较轻,存在显著性差异(P0.05).(5)生活质量方面:KPS评分在治疗前后相比,两组不具有显著性差异(P0.05)。结论:养阴清咽饮可以延缓鼻咽癌患者放射性口腔干燥症的发生时间,减轻口干程度;可减少放疗副反应的发生,具有改善临床症状、提高生存质量的作用,临床应用安全,值得推广。
[Abstract]:Objective: to observe the clinical effect of Yangyin Qingyan decoction (YQYY) on patients with radiation dry mouth, and to provide an objective basis for the prevention and treatment of radioactive xerostomia by traditional Chinese medicine (TCM). Methods: open randomized controlled trial was used to study 59 cases in two groups, 29 cases in treatment group and 30 cases in control group, and 59 cases were randomly divided into two groups, 29 cases in treatment group, 30 cases in control group, 29 cases in treatment group, 30 cases in control group, 29 cases in treatment group and 30 cases in control group. The treatment group was treated with Yangyin Qingyan decoction combined with radiotherapy, while the control group was treated with radiotherapy alone. The severe adverse reactions in both groups were treated in the same symptomatic manner. The completion rate of radiotherapy was compared between the two groups. The time and cumulative radiation dose of xerostomia, dry mouth grade, saliva flow rate, adverse reaction and safety were analyzed by SPSS 19.0 statistical software. Results the study included 59 patients, including 29 patients in the treatment group, 29 patients in the treatment group, 29 patients in the treatment group, and 29 patients in the treatment group. In the control group, there were 7 patients who dropped out and eliminated during the treatment, and 52 patients were included in the statistical analysis. At first, the composition analysis of 59 patients with nasopharyngeal carcinoma found that the sex and age of the two groups of patients. The clinical stage and KPS score were all 0.05 by statistical analysis, that is to say, there was no significant difference between the two groups in the above aspects. The time and cumulative radiation dose of dry mouth appeared in the two groups were comparable. The time of dry mouth appeared in the treatment group was later than that in the control group. There was significant difference between the two groups (P 0.05) and the cumulative dose of dry oral radiation was significantly different between the two groups (P < 0.05). The degree of oropharynx reaction in the treatment group was less than that in the control group, and there was a significant difference in the oral and pharyngeal reaction between the two groups (P < 0.05). There was significant difference in saliva velocity between the two groups: there was significant difference between the two groups before and after radiotherapy, which indicated that the larger the dose of radiotherapy, the greater the damage to salivary gland and the smaller the velocity of saliva. There was significant difference in the decrease of salivary velocity between the two groups after radiotherapy (P0.05N. 4) dry degree of mouth: the dry degree of mouth in the treatment group after radiotherapy was significantly lighter than that in the control group, and there was significant difference in the quality of life between the two groups (P0.05. 5) the weight KPS score was compared before and after treatment, and there was a significant difference between the two groups in terms of quality of life before and after treatment. Conclusion: Yangyin Qingyan decoction can delay the occurrence time of radiation-induced xerostomia in patients with nasopharyngeal carcinoma, reduce the degree of dry mouth, reduce the incidence of side effects of radiotherapy, and improve the clinical symptoms. Improve the effect of quality of life, clinical application safety, it is worth popularizing.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R273

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