祛瘀化痰复方治疗高血压的临床研究
发布时间：2018-03-13 18:07
本文选题：高血压 切入点：加味半夏白术天麻汤 出处：《辽宁中医药大学》2016年硕士论文 论文类型：学位论文
【摘要】：目的:本研究通过应用“祛瘀化痰”中药加味半夏白术天麻汤治疗痰瘀互结型原发性高血压患者,观察该药对高血压患者的临床疗效的影响,证明“祛瘀化痰”治疗高血压的临床疗效,通过疗效指标的变化,进一步揭示“祛瘀化痰,活血通络”治疗高血压的病理机制。为明确“祛瘀化痰”与高血压的病机实质的相关性研究提供新的方法和客观依据。材料与方法:本试验全部研究对象均来自辽宁中医药大学附属医院门诊2015年1月至2015年6月的门诊就诊患者,其中符合此次分析标准的高血压患者共90例。将被纳入的患者随机分组成治疗组和对照组,其中治疗组45例,对照组45例。对照组予苯磺酸氨氯地平片口服,治疗组在对照组的治疗基础上再予加味半夏白术天麻汤口服,每次1剂,每日2次,两组疗程均为1月。观察两组患者治疗前后诊室血压、24h动态血压、中医证候积分、生活质量量表评分、临床单项疗效,并观察记录患者治疗期间的基本生命体征,不良反应。结果:1.治疗前两组患者在性别、年龄、病程、家族史、体重、中医证候积分、诊室血压、24h动态血压、临床单项疗效、生活质量量表评分等方面进行比较,均无显著差异(P0.05),说明两组患者具有可比性,随机分组效果较好。2.治疗后两组患者诊室血压比较,治疗组总有效率为97.37%,对照组为78.84%,有统计学差异(P0.05),且治疗组诊室血压降低水平优于对照组,诊室血压改善水平具有显著性差异(P0.01)。3.治疗前后两组患者24h动态血压变化比较,有显著性差异(P值均0.01),且治疗组优于对照组。治疗后两组患者d SBP、n SBP和24h SBP比较,有统计学差异(P值均㩳0.05);两组患者d DBP、n DBP和24h DBP比较,有显著性差异(P值均0.01)。4.治疗后治疗组与对照组高血压中医证候积分变化比较,治疗组总有效率97.78%,对照组为83.42%,治疗组的疗效优于对照组。5.治疗后两组患者临床单项疗效比较,有统计学差异(P0.05),说明治疗组在缓解头痛、眩晕、呕吐痰涎、胸闷等症状方面疗效优于对照组。6.治疗后两组患者生活质量量表积分均降低,有统计学差异性(P0.05),且治疗组疗效优于对照组(P0.05),说明加味半夏白术天麻汤可以显著提高患者生活质量。7.在治疗期间,两组患者均未出现明显的不良反应出现,安全性和耐受性良好。结论:1.加味半夏白术天麻汤可显著降低痰瘀互结型高血压患者的血压水平。2.加味半夏白术天麻汤可显著降低痰瘀互结型高血压患者的中医证候积分,缓解头痛、头晕、气短、乏力、手足麻木等临床症状。3.加味半夏白术天麻汤可显著提高高血压患者生活质量。
[Abstract]:Objective: to study the clinical effect of Banxia Atractylodes Tianma decoction (Banxia Atractylodes Tianma decoction) on patients with essential hypertension. It is proved that "dispelling blood stasis and resolving phlegm" is the clinical curative effect of hypertension. Through the change of curative effect index, it is further revealed that "dispelling blood stasis and resolving phlegm," To provide a new method and objective basis for the study of the correlation between "removing blood stasis and resolving phlegm" and the pathogenesis of hypertension. Materials and methods: all the subjects of this study come from. The outpatients of the affiliated Hospital of Liaoning University of traditional Chinese Medicine from January 2015 to June 2015, The patients were randomly divided into two groups: treatment group (n = 45) and control group (n = 45). The control group (n = 45) received amlodipine benzenesulfonic acid tablets orally, and the control group (n = 45) received amlodipine benzenesulfonate orally. The treatment group was treated with modified Banxia Atractylodes Tianma decoction on the basis of the treatment of the control group, once a time, twice a day, the course of treatment was January. The blood pressure of the two groups was observed before and after treatment, and 24 hours ambulatory blood pressure was observed, and the TCM syndromes score was observed. Quality of life scale score, clinical single curative effect, and observe and record patients' basic vital signs, adverse reactions during treatment. Results: before treatment, the two groups of patients in gender, age, course of disease, family history, weight, TCM syndrome score, There was no significant difference in 24 h ambulatory blood pressure, single clinical curative effect and quality of life scale score between the two groups, indicating that the two groups were comparable, and the effect of randomized grouping was better. 2. After treatment, the blood pressure of the two groups was compared. The total effective rate of the treatment group was 97.37 and that of the control group was 78.84. The difference was statistically significant (P 0.05), and the blood pressure in the treatment group was lower than that in the control group, and the improvement level of blood pressure in the treatment group was significantly different (P 0.01 路3). The changes of ambulatory blood pressure in 24 hours before and after treatment were compared between the two groups. There was significant difference between the two groups (P < 0.01), and the treatment group was superior to the control group (P < 0.05). After treatment, there were significant differences in the d SBPn SBP and 24 h SBP between the two groups. D DBP n DBP and 24 h DBP were significantly different between the two groups. After treatment, the scores of TCM syndromes in the treatment group and the control group were higher than those in the control group. The total effective rate of the treatment group was 97.78 and that of the control group was 83.42. The curative effect of the treatment group was better than that of the control group .5.After the treatment, there was a statistical difference between the two groups (P 0.05), indicating that the treatment group was relieving headache, dizziness, vomiting, sputum and salivation. The curative effect of chest tightness and other symptoms was better than that of control group .6.After treatment, the scores of quality of life scale decreased in both groups. The difference was statistically significant (P 0.05), and the curative effect of the treatment group was better than that of the control group (P 0.05), which indicated that the modified Banxia Atractylodes Tianma decoction could significantly improve the quality of life of the patients. During the treatment period, there were no obvious adverse reactions in both groups. Conclusion: the modified Banxia Atractylodes Tianma decoction can significantly reduce the blood pressure level of hypertension patients with phlegm and blood stasis. 2. The modified Banxia Atractylodes Tianma decoction can significantly reduce the TCM syndromes integral of hypertension patients with phlegm and blood stasis. Relieving headache, dizziness, shortness of breath, fatigue, numbness of hand and foot and other clinical symptoms .3.Adjusted Banxia Atractylodes Tianma decoction can significantly improve the quality of life of patients with hypertension.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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本文编号：1607535
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