止痒润肤汤联合冰黄肤乐软膏治疗慢性湿疮（脾蕴瘀热证）的临床观察

发布时间：2018-03-27 08:00

本文选题：止痒润肤汤　切入点：清火散瘀　出处：《成都中医药大学》2016年硕士论文

【摘要】：研究目的通过临床研究,系统评价根据“清火散瘀、培土祛湿”法拟定的“止痒润肤汤”治疗慢性湿疮(脾蕴瘀热证)的临床疗效、安全性、复发率,为临床治疗慢性湿疮提供一种新的治疗思路。研究方法本研究选取成都中医药大学附属医院皮肤科门诊中符合纳入标准的60例患者,将其随机分为治疗组和对照组。治疗组30例,予中药止痒润肤汤口服；对照组30例,予地氯雷他定分散片口服,两组均予冰黄肤乐软膏外擦。每周复诊1次,连续治疗4周。用SPSS21.0软件对数据进行统计分析,对比患者治疗前后症状、体征改善情况及复发率等,做出相关临床判定。研究结果本研究共完成临床病例58例,治疗组29例,治愈5例,显效9例,有效9例,无效6例,有效率为79.31%；对照组29例,治愈2例,显效5例,有效11例,无效11例,有效率为62.07%。经统计学分析,两组有效率差异具有统计学意义(P0.05),说明治疗组临床有效率优于对照组；在改善瘙痒程度方面,两组差异不具有统计学意义(P0.05),说明治疗组与对照组疗效相当；在改善皮疹情况及全身伴随症状方面,两组差异具有统计学意义(P0.05),说明治疗组疗效优于对照组；对两组痊愈及显效的患者进行复发情况的比较,差异具有统计学意义(P0.05),说明治疗组在防止慢性湿疮复发方面明显优于对照组。结论由“清火散瘀、培土祛湿”法拟定的“止痒润肤汤”能有效改善慢性湿疮患者的局部及全身症状,疗效优于对照组,复发率低,无明显不良反应,值得广泛应用于临床。
[Abstract]:Objective to systematically evaluate the clinical efficacy, safety and recurrence rate of "Zhitao Runfu decoction" in the treatment of chronic wet sore (spleen stasis heat syndrome) according to the method of "clearing fire and dissipating stasis and nourishing soil and dispelling dampness". In this study, 60 patients who met the inclusion criteria in dermatology outpatient department of Chengdu University of traditional Chinese Medicine were selected. It was randomly divided into treatment group and control group. 30 cases in treatment group were treated with Zhiyao Runfu decoction, 30 cases in control group were treated with desloratadine dispersible tablets, both groups were treated with binghuangfule ointment, and treated once a week, and 30 cases in control group were treated with desloratadine dispersible tablets. After 4 weeks of continuous treatment, the data were statistically analyzed with SPSS21.0 software, and the symptoms, signs and recurrence rate of the patients were compared before and after treatment. The results showed that there were 58 cases in this study and 29 cases in the treatment group. 5 cases were cured, 9 cases were effective, 9 cases were effective, 6 cases were ineffective, the effective rate was 79.31. In the control group, 29 cases were cured, 2 cases were cured, 5 cases were effective, 11 cases were effective, 11 cases were ineffective, and the effective rate was 62.07%. The difference of effective rate between the two groups was statistically significant (P 0.05), which indicated that the clinical effective rate of the treatment group was better than that of the control group, but the difference between the two groups was not statistically significant in improving the degree of pruritus, which indicated that the curative effect of the treatment group was similar to that of the control group. The difference between the two groups was statistically significant (P 0.05), indicating that the curative effect of the treatment group was better than that of the control group. The difference was statistically significant (P 0.05), which indicated that the treatment group was superior to the control group in preventing the recurrence of chronic wet sore. The "Zhitao Runfu decoction" developed by the method of "Peitu Qushi" can effectively improve the local and systemic symptoms of patients with chronic wet sores. The curative effect is superior to that of the control group, the recurrence rate is low and there is no obvious adverse reaction, so it is worthy of being widely used in clinical practice.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

【参考文献】