谢晶日教授治疗腹泻型肠易激综合征用药规律的研究

发布时间：2018-03-29 17:46

本文选题：腹泻型肠易激综合征　切入点：用药规律　出处：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:通过对谢晶日教授治疗的腹泻型肠易激综合征患者用药统计分析,探讨谢晶日教授治疗本病的用药规律。方法:收集自2011年1月至2016年12月期间于黑龙江中医药大学附属第一医院谢晶日教授门诊就诊,经谢晶日教授诊治的腹泻型肠易激综合征患者详细的病历资料。使用Microsoft Excel建立数据库,进行频数分析,得出高频中药,常用的药类、四气、五味及归经;应用IBMSPSSStatistics18.0软件进行聚类分析,得出常用药对及药物组合。通过统计结果,探讨谢晶日教授治疗腹泻型肠易激综合征临床用药规律。结果:根据纳入标准收集得到168例患者处方,统计得出治疗本病所有涉及中药115味,总使用频数为4013次;其中使用频率在50次以上的药物为32味,累计频率达74.36%,其中柴胡、白芍、薏苡仁、防风、山药、白术、茯苓、白扁豆、陈皮、党参、甘草、黄芪、砂仁、苍术、五味子、补骨脂、诃子、肉豆蔻、吴茱萸为治疗本病的核心用药。涉及用药种类14类,其中补虚药频率最多,其次为收涩药、理气药。统计得出药物的四气中以温性药使用为最多,其余依次为平性、寒性;药味中的前三位是甘味、苦味、辛味;归经前四位归经为脾经、肺经、胃经、肝经。经聚类分析得到9对常用药对和6组药物的常用组合。结论:1.柴胡、白芍、薏苡仁、防风、山药、白术、茯苓、白扁豆、陈皮、党参、甘草、黄芪、砂仁、苍术、五味子、补骨脂、诃子、肉豆蔻、吴茱萸为谢晶日教授治疗腹泻型肠易激综合征的核心药物。2.补虚药、收涩药、理气药为谢晶日教授治疗腹泻型肠易激综合征的常用药物类别。3.甘味、苦味、辛味;温性、平性;脾经、肺经、胃经、肝经为谢晶日教授治疗腹泻型肠易激综合征用药的主要性味与归经。4.疏肝健脾化湿,温肾固涩是谢晶日教授治疗腹泻型肠易激综合征的基本方法。
[Abstract]:Objective: to analyze the drug use in patients with diarrhea irritable bowel syndrome treated by Professor Xie Jingri. Methods: from January 2011 to December 2016, Professor Xie Jingri, Professor of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine, was selected to visit the clinic. The detailed medical records of the patients with diarrhea irritable bowel syndrome treated by Professor Xie Jingri. The database was established by Microsoft Excel, and the frequency analysis was carried out. The high frequency traditional Chinese medicine, the commonly used drugs, the four qi, five flavors and the return of the meridian were obtained. By cluster analysis with IBMSPSSStatistics18.0 software, the common drug pairs and drug combinations were obtained. Through the statistical results, Professor Xie Jingri was studied for clinical drug use in the treatment of diarrhea irritable bowel syndrome. Results: according to the inclusive criteria, 168 prescriptions were obtained. Statistics show that all the drugs involved in the treatment of this disease are 115 kinds of Chinese medicine, the total frequency of use is 4013 times; among them, 32 kinds of drugs are used more than 50 times, and the cumulative frequency is 74.36. Among them, Bupleurum, Radix Paeoniae Paeoniae, Coix lachryma seed, Astragalus, yam, Atractylodes macrocephala, Poria cocos, White lentils, Chen Pei, Codonopsis, licorice, Astragalus, Amomum, Atractylodes, Schisandra, Psoralea, Chekophyllum, nutmeg and Evodia rutaecarpa are the core drugs for the treatment of this disease. There are 14 kinds of drugs involved in the treatment, among which tonifying and deficiency drugs are the most frequent, followed by astringent drugs. According to statistics, among the four kinds of drugs, warm drugs are the most used, and the rest are flat and cold; the first three places of medicinal taste are sweet, bitter and Xin Wei; the first four of them are spleen, lung, stomach, and so on, and the first four are spleen meridian, lung meridian and stomach meridian. Conclusion: 1. Radix Bupleurum, Radix Paeoniae Alba, Coix seed, Fangfeng, yam, Atractylodes macrocephala, Poria cocos, White lentils, Old Peel, Codonopsis, Glycyrrhiza, Astragalus, Amomum, Atractylodes, Atractylodes Atractylodes. Schisandra, psoralen, chebulae, nutmeg, Evodia rutaecarpa are the core drugs used by Xie Jingri to treat diarrhea irritable bowel syndrome. Qi regulating medicine is the common medicine category of Professor Xie Jingri's treatment of diarrhea irritable bowel syndrome .3.Sweet, bitter, symplectic, warm, flat, spleen, lung, stomach, The liver meridian is the main characteristic taste of professor Xie Jingri's treatment of diarrhea irritable bowel syndrome. 4. Soothing liver and invigorating spleen and transforming dampness and warming kidney and astringement are the basic methods of Professor Xie Jingri's treatment of diarrhea irritable bowel syndrome.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R249;R259

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