调更益经汤对肾虚血瘀型围绝经期骨质疏松症的临床疗效研究

发布时间：2018-04-11 16:08

本文选题：调更益经汤 + 肾虚血瘀型　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察调更益经汤治疗围绝经期妇女肾虚血瘀型骨质疏松症的临床疗效,以便于更好地寻找办法解决其不适症状。方法:于青岛市海慈医疗集团2014年3月至2015年6月中医妇科门诊和病房所筛选出64例诊断为本病的患者,然后把64例患者随机分为了治疗组和对照组。治疗组服用导师徐慧军教授自拟方调更益经汤,对照组患者服用仙灵骨葆胶囊,治疗2个疗程。观察两组患者治疗前后的临床症状(腰膝酸软、颈背疼痛、眩晕耳鸣、失眠多梦、健忘、经少、经闭)及血清碱性磷酸酶(ALP)、血清钙、促卵泡生成素(FSH)、雌二醇(E2)以及骨密度(左侧髋骨、第1-4腰椎正侧位骨密度)的变化。结果:本次临床研究结果表明:(1)治疗组的总有效率可达83%,对照组的总有效率为63%,(P0.05),说明了调更益经汤对治疗本病更具有优势。(2)两组患者的临床症状总积分相对于以前均有所下降,治疗组优于对照组,尤其对于(腰膝酸软、颈背疼痛)的主要症状方面。(3)在内分泌方面,两组在治疗后的E2、FSH水平均有所改善,两组在治疗前后相比具有显著性差异(p0.05);组间比较无明显区别(p0.05)。表明在改善激素水平方面调更益经汤具有更好的疗效。(4)两组治疗后的骨密度均较治疗前略有所上升,在腰椎骨密度方面治疗前后比较有显著性差异(p0.05),组间比较有显著性差异(p0.05),治疗组要优于对照组。在髋骨骨密度方面治疗前后比较有显著性差异(P0.05),组间比较无显著差异(p0.05),表明调更益经汤在改善髋骨骨密度方面无明显优势。结论:调更益经汤对本病的治疗较为显著,能够改善生殖内分泌、提高骨密度、改善血清碱性磷酸酶(ALP)、血清钙的水平以达到改善临床症状的目的,但由于骨密度变化较慢,有待继续观察。
[Abstract]:Objective: to observe the clinical effect of Tiaogeng Yijing decoction in treating peri-menopausal women with kidney deficiency and blood stasis type osteoporosis in order to find a better solution to its unwell symptoms.Methods: from March 2014 to June 2015, 64 patients were selected from TCM gynecological outpatient department and ward of Qingdao Haici Medical Group, and 64 patients were randomly divided into treatment group and control group.The treatment group was treated with Professor Xu Huijun's own prescription Tiaogeng Yijing decoction and the control group was treated with Xianling Gubao capsule for 2 courses of treatment.To observe the clinical symptoms before and after treatment (waist and knee weakness, neck pain, vertigo tinnitus, insomnia and dream, amnesia, menstrual obstruction), serum alkaline phosphatase (ALP), serum calcium,Changes of follicle stimulating hormone (FSH), estradiol (E2) and bone mineral density (left hip, 1-4 lumbar vertebrae positive and lateral BMD).Results: the results of this clinical study show that the total effective rate of the treatment group can reach 833%, and the total effective rate of the control group is 63% (P 0.05), which indicates that Tiaogenyi Jing decoction has more advantages in the treatment of this disease.The treatment group was superior to the control group, especially for the main symptoms (waist and knee pain, neck pain) in endocrine, the two groups after the treatment of E2FSH levels improved,There was significant difference between the two groups before and after treatment (P 0.05), but there was no significant difference between the two groups (P 0.05).It indicated that Tiao Gengyi Jing decoction had better curative effect in improving hormone level.) the bone mineral density of both groups after treatment was slightly higher than that before treatment.There were significant differences in bone mineral density of lumbar vertebrae before and after treatment (P 0.05) and between groups (P 0.05). The treatment group was better than the control group.There was significant difference in bone mineral density of hip before and after treatment (P 0.05), but there was no significant difference between groups (P 0.05), which indicated that Tiaogeng Yijing decoction had no obvious advantage in improving bone mineral density of hip.Conclusion: Tiaogeng Yijing decoction can improve reproductive endocrine, bone mineral density, serum alkaline phosphatase and serum calcium to improve clinical symptoms, but the change of bone mineral density is slow.It remains to be seen.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.116

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