补肾润燥方对干燥综合征肝肾阴虚证中老年女性患者外分泌腺功能及性激素的影响

发布时间：2018-04-19 02:11

本文选题：干燥综合征 + 肝肾阴虚证　；参考：《中医杂志》2017年14期

【摘要】：目的观察补肾润燥方治疗干燥综合征中老年女性患者的临床疗效。方法将56例干燥综合征肝肾阴虚证中老年女性患者随机分为治疗组和对照组各28例。对照组采用口服硫酸羟氯喹片每次100 mg、每日两次治疗;治疗组采用中药补肾润燥方治疗,每日1剂,两组均治疗12周。分别在治疗前后进行患者主观症状(ESSPRI)及活动指数(ESSDAI)评分,双眼基础泪液试验(Schirmer's试验)、唾液流率检测,以及性激素、血沉、C反应蛋白(CRP)、球蛋白、Ig G检测,并观察两组临床疗效。结果治疗组完成25例,临床疗效总有效率为76%;对照组完成19例,总有效率为21%,治疗组疗效优于对照组(P0.01)。治疗后治疗组ESSPRI、Schirmer's试验、唾液流率均有改善(P0.01),且治疗组较对照组ESSPRI下降,Schirmer's试验、唾液流率改善(P0.05);两组治疗前后及组间比较ESSDAI评分差异无统计学意义(P0.05)。治疗后治疗组睾酮、脱氢表雄酮硫酸酯水平较本组治疗前及对照组治疗后均升高(P0.05),两组治疗前后及组间比较,雌二醇水平差异无统计学意义(P0.05)。两组治疗前后及组间比较,血沉、CRP、球蛋白、Ig G水平差异无统计学意义(P0.05)。结论补肾润燥方在改善干燥综合征肝肾阴虚证中老年女性患者主观症状、唾液流率、泪液分泌功能方面具有较好疗效,其机制可能与调节性激素水平有关。
[Abstract]:Objective to observe the clinical effect of Bushen Runzao recipe (BYR) on elderly women with Sjogren syndrome.Methods 56 elderly women with Sjogren syndrome were randomly divided into treatment group (n = 28) and control group (n = 28).The control group was treated with 100 mg hydroxychloroquine sulfate tablets twice a day, while the treatment group was treated with Bushen Runnao recipe once a day for 12 weeks.The subjective symptoms (ESSPRI) and activity index (ESSDAI) were evaluated before and after treatment, and the clinical efficacy of the two groups was observed. The clinical efficacy of the two groups was also observed. The saliva flow rate, sex hormone, erythrocyte sedimentation rate C-reactive protein (ESR), and globulin Ig G were measured.Results 25 cases were completed in the treatment group, the total effective rate was 76%, and 19 cases in the control group and 21 cases in the control group. The curative effect of the treatment group was better than that of the control group (P 0.01).After treatment, the saliva flow rate of the treatment group was improved by ESSPRI Schirmerstest, and compared with the control group, the ESSPRI decreased and the saliva flow rate improved P0.05in the treatment group, and there was no significant difference in the ESSDAI score between the two groups before and after treatment.After treatment, the levels of testosterone and dehydroepiandrosterone sulfate in the treatment group were higher than those in the control group and before treatment. There was no significant difference in estradiol levels between the two groups before and after treatment.There was no significant difference in erythrocyte sedimentation rate (CRP) and globulin Ig G levels between the two groups before and after treatment (P 0.05).Conclusion Bushen Runzao recipe has a better effect on improving subjective symptoms, saliva flow rate and tear secretion function in elderly women with liver and kidney yin deficiency syndrome in Sjogren's syndrome, and its mechanism may be related to the regulation of sex hormone level.
【作者单位】：上海中医药大学附属曙光医院;
【基金】：上海市卫生和计划生育委员会中医药科研基金(2014LP095A) 2014年上海青年医师培训资助计划
【分类号】：R259

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