益气养血化瘀解毒法干预放射性肺炎的临床研究

发布时间：2018-04-19 21:34

本文选题：放射性肺炎 + 放疗　；参考：《辽宁中医杂志》2017年12期

【摘要】：目的:通过益气养血化瘀解毒法联合西医常规治疗,寻找更加科学有效的联合治疗手段,改善患者的急性期症状,降低放射性肺炎的发生率,并探究其可能的作用机制。方法:40例患者采用随机数字表法随机分为治疗组和对照组各20例,对照组采用西医常规治疗,激素泼尼松联合抗生素头孢呋辛,治疗组在对照组的基础上加用以益气养血化瘀解毒为法的中药汤剂口服。两组均在出现放射性肺炎症状时开始治疗,共观察6周。各组于治疗前后分别观察症状缓解效果、TGF-β1水平以及不良反应的发生情况,评价临床疗效。结果:与对照组比较,治疗组在干咳、气喘、呼吸困难这3个症状的改善显著,缓解率更高(P0.05);治疗组在治疗后TGF-β1水平明显低于对照组(P0.05);与对照组相比,治疗组的不良反应发生率更低(P0.05)。结论:益气养血化瘀解毒法联合常规西医治疗相比单纯的西医常规方式治疗放射性肺炎,在主要临床症状的缓解上有一定的优势,且不良反应发生率小,安全性高,其机制可能是通过对TGF-β1水平的抑制。
[Abstract]:Objective: to find a more scientific and effective method to improve the acute symptoms of patients, reduce the incidence of radiation pneumonia, and explore the possible mechanism by combining the routine therapy of replenishing qi, nourishing blood and removing blood stasis and detoxifying toxin in combination with western medicine. Methods 40 patients were randomly divided into treatment group (n = 20) and control group (n = 20). On the basis of the control group, the treatment group was treated with traditional Chinese medicine decoction for nourishing qi, nourishing blood and removing blood stasis and detoxification. The patients in both groups were treated with radiation pneumonia for 6 weeks. The level of TGF- 尾 1 and the occurrence of adverse reactions were observed before and after treatment, and the clinical efficacy was evaluated. Results: compared with the control group, the symptoms of dry cough, asthma and dyspnea in the treatment group were significantly improved, the remission rate was higher than that in the control group, the level of TGF- 尾 1 in the treatment group was significantly lower than that in the control group after treatment, and compared with the control group, The incidence of adverse reactions in the treatment group was lower than that in the control group (P 0.05). Conclusion: compared with conventional western medicine, the combination of supplementing qi, nourishing blood and removing blood stasis and detoxification has some advantages in relieving the main clinical symptoms, and the incidence of adverse reactions is small and the safety is high. The mechanism may be the inhibition of TGF- 尾 1 level.
【作者单位】：南京中医药大学基础医学院;第二军医大学附属长海医院中医科;南京中医药大学明基教学医院;
【基金】：国家自然科学基金(81503485) 南京市科技计划项目(201402054)
【分类号】：R259

【相似文献】