男性甲基苯丙胺成瘾者记忆形成的中医证素特征研究

发布时间：2018-04-29 02:19

本文选题：甲基苯丙胺成瘾者 + 中医证素　；参考：《福建中医药大学》2016年硕士论文

【摘要】：目的：应用课题组研发的“中医健康状态辨识系统”,结合生物反馈治疗仪,观察并记录男性甲基苯丙胺成瘾者脑波治疗前后脑电、心电、心电变异率等信号与中医证素的变化,探讨男性甲基苯丙胺成瘾者成瘾记忆形成的可能的中医内在机制,完成中医健康辨识系统临床验证,为临床上防治甲基苯丙胺成瘾者毒瘾复发提供新的思路。方法：规范采集104例自愿参加调查的男性甲基苯丙胺成瘾者四诊资料,其中福州则徐自愿戒毒所54例(简称自愿组),公安强制戒毒所50例(简称强戒组),应用课题组研发的中医健康状态辨识系统分析男性甲基苯丙胺成瘾者中医证素特征。同时在自愿组中开展生物反馈治疗。自愿组随机分成两组,其中一组在药物治疗基础上应用生物反馈仪治疗(简称生物反馈组)；另一组为单独用药物治疗(简称对照组),每组均27例,两组的药物治疗方案均一致。应用中医健康状态辨识系统,提取中医证素特征观察生物反馈治疗前后脑电、心电、心电变异率等信号与中医证素的变化,完成中医健康状态辨识系统临床验证。结果：1.甲基苯丙胺成瘾者中医证素特征实性病性证素以气滞、湿、痰为主；虚性病性证素以血虚和气虚为主；病位证素以肝、肾为主。强戒组与自愿组两组证素在脾、肝、肾、胆、痰、饮、湿、阴虚、阳虚、气滞、气虚、血虚、肺、心、胃上存在差异性(P0.05)。生物反馈组与对照组在肝、心、痰、饮、湿、阳气滞、血虚存在差异(P0.05)。2.强戒组对工作、娱乐、生活兴趣的下降与脾、心、气滞、血虚、痰、阳虚证素相关(P0.05)；同家人或朋友的矛盾与肝证素相关(P0.05)。自愿组对工作、娱乐、生活兴趣的下降与肺、肾、心、心神、气滞、阴虚证素相关(P0.05)；同家人或朋友的矛盾与肝证素相关(P0.05)。3.生物反馈组治疗前左脑θ波、SMR波、δ波与肝、气滞、肾、湿、胆、痰证素相关(P0.05)；右脑0波、.SMR波、Υ波的变化与肝、肺、肾、心、胆、气滞、血虚、湿、阳虚证素存在相关(P0.05)；FFTθ、FFTSMR与肝、气滞、肾、湿、阳虚存在相关(P0.05)。生物反馈组治疗后左脑0波、SMR波、p波、δ波与肝、气滞、肾、胆、痰、饮证素相关(P0.05)；右脑θ波、SMR波、Υ波的变化与肝、肾、心、胆、气滞、血虚、湿、饮证素存在相关(P0.05)；FFTθ、FFTSMR与肝、肾、湿、阳虚存在相关(P0.05)。4.生物反馈组治疗前后心电信号无差异性,同时与中医证素的相关性无变化。影响生物反馈组BVP变化的主要证素为肝、胆、肾、气滞、阴虚(P0.05)。影响LF/HF、 LF(%)、HF(%)变化的证素主要为肝、脾、胃、痰、湿(P0.05)结论：1.甲基苯丙胺成瘾涉及多脏腑功能失调,气血津液俱损的共同结果,在证候上多表现为虚实夹杂。血虚、气虚、阳虚、阴虚以及气滞、湿、痰为甲基苯丙胺成瘾者的主要病性特征。而肝、肾为甲基苯丙胺成瘾者主要病位特征。2.影响甲基苯丙胺成瘾者精神情绪异常以肝、心、肾的危害最为显著,肝郁气滞、心血亏虚、肾虚精亏为其主要表现。生物反馈治疗甲基苯丙胺成瘾者可影响证素的变化,主要表现在肝、心、痰、饮、湿、气滞、血虚。3.甲基苯丙胺成瘾者脑波干预治疗前后部分脑电、心电与中医证素存在相关性。甲基苯丙胺脑电指标可能对肝、肾、肺、心、胆、气滞、痰、湿、阳虚、血虚证素的诊断有参考价值；甲基苯丙胺成瘾者脑波治疗后部分脑电指标(α波、FFTa)有所改善,提示脑电指标可能作为甲基苯丙胺成瘾者生物反馈脑波治疗疗效评价的参考；部分心电指标(BVP、LF/HF、LF(%)、HF(%))可能对胆、肝、肾、脾、胃、气滞、湿、痰、阴虚证素的诊断有参考价值。4.课题组研发的中医健康状态辨识系统能较好的体现甲基苯丙胺成瘾者中医证素特征。
[Abstract]:Objective : To study the traditional Chinese medicine health status identification system developed by the study group , and observe and record the changes of EEG , ECG , ECG and other signals in male methamphetamine addicts before and after brain wave therapy .
The traditional Chinese medicine health status identification system was used to extract the changes of EEG , ECG , ECG and other signals before and after the biological feedback treatment , and the clinical verification of the TCM health status identification system was completed .
The syndrome of deficiency of sexually transmitted diseases is mainly characterized by blood deficiency and deficiency of qi .
There was a difference in spleen , liver , kidney , gallbladder , phlegm , yin deficiency , yin deficiency , yang deficiency , qi stagnation , qi deficiency , blood deficiency , lung , heart and stomach ( P0.05 ) .
The relationship with family members or friends was related to liver syndrome ( P0.05 ) . The decline of interest of work , entertainment and living was correlated with lung , kidney , heart , mind , qi stagnation and yin deficiency syndrome ( P0.05 ) .
Compared with family members or friends ( P0.05 ) . 3 . Left brain . theta . wave , SMR wave and delta wave were correlated with liver , qi stagnation , kidney , dampness , gallbladder and phlegm syndrome ( P0.05 ) .
Right brain 0 wave , . SMR wave and gamma wave were correlated with liver , lung , kidney , heart , gallbladder , qi stagnation , blood deficiency , wet and yang deficiency syndrome ( P0.05 ) .
The results showed that FFTSMR correlated with liver , qi stagnation , kidney , wet and yang deficiency ( P0.05 ) . Left brain 0 wave , SMR wave , p wave , 未 wave were correlated with liver , qi stagnation , kidney , gallbladder , sputum and yin syndrome ( P0.05 ) .
The changes of right brain theta wave , SMR wave and gamma wave were correlated with liver , kidney , heart , gallbladder , qi stagnation , blood deficiency , dampness and yin syndrome ( P0.05 ) .
The changes of liver , heart , kidney , deficiency of kidney , yin deficiency and stagnation of qi , spleen , stomach , deficiency of kidney and deficiency of kidney are the main causes of the change of liver , spleen , stomach , phlegm and yin deficiency ( P0.05 ) . There is a reference value for the diagnosis of phlegm , dampness , yang deficiency and blood deficiency syndrome ;
The EEG index ( 伪 - wave , FFTa ) was improved after brain wave therapy of methamphetamine addicts , suggesting that EEG markers may be used as a reference for the evaluation of therapeutic effect of brain wave therapy for methamphetamine addicts ;
Some ECG indexes ( BVP , LF / HF , LF ( % ) , HF ( % )) may be valuable for the diagnosis of gallbladder , liver , kidney , spleen , stomach , qi stagnation , dampness , phlegm and yin deficiency syndrome .

【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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