清火解毒消瘿汤治疗桥本甲状腺炎心肝火旺证的临床研究

发布时间：2018-04-29 12:34

本文选题：桥本甲状腺炎 + 心肝火旺　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:本研究旨在观察清火解毒消瘿汤治疗心肝火旺型桥本甲状腺炎的临床疗效,并探讨其相关作用机理。方法:将90例符合纳入标准的心肝火旺型桥本甲状腺炎患者,随机分成两组,试验组45例,对照组45例。试验组给予清火解毒消瘿汤,对照组给予夏枯草口服液,疗程均为12周。观察治疗前后两组中医证候积分、血中甲状腺激素水平、甲状腺自身抗体水平、甲状腺峡部厚度等指标,并对相关数据进行统计分析,评价清火解毒消瘿汤的临床疗效。结果:试验组总有效率为84.44%,对照组总有效率为53.33%,两组临床疗效比较,差异有统计学意义(PO.O1)。两组中医症状积分治疗前后和治疗后组间比较,有显著统计学意义(P0.01)。试验组在改善颈前瘿肿、烦躁易怒、口干口苦、怕热多汗、神疲乏力、少寐多梦症状方面明显优于对照组(PO.O1)。两组FT3、FT4、TSH值比较,HT甲亢组治疗前后有统计学意义(P0.01),治疗后组间比较无统计学意义(P0.05);两组TPOAb、TGAb水平治疗后比较,差异具有统计学意义(P0.01)。两组HT甲亢患者甲状腺峡部厚度比较,两组治疗前后差异具有统计学意义(P0.05);治疗后组间比较差异无统计学意义(P0.05)。结论:清火解毒消瘿汤可以明显改善心肝火旺型桥本甲状腺炎患者的临床症状,降低甲状腺自身抗体水平,调节甲状腺功能并能缓解甲状腺肿大,且无明显不良反应,是一种安全有效的治疗方法。
[Abstract]:Objective: to observe the clinical effect of Qinghuo jiedu Xiaoying decoction in treating Hashimoto's thyroiditis of heart-liver-Huowang type and to explore its related mechanism. Methods: 90 patients with Hashimoto's thyroiditis were randomly divided into two groups: the experimental group (n = 45) and the control group (n = 45). The experimental group was given Qinghuo jiedu Xiaoying decoction and the control group was given Prunella vulgaris oral liquid for 12 weeks. Observe the TCM syndromes integral, serum thyroid hormone level, thyroid autoantibody level, thyroid isthmus thickness and other indexes before and after treatment, and carry on the statistical analysis to the related data, evaluate the clinical curative effect of Qinghuo jiedu Xiaoying decoction. Results: the total effective rate of the trial group was 84.44 and the total effective rate of the control group was 53.33.The difference between the two groups was statistically significant. There was significant difference between the two groups before and after the treatment. The treatment group was superior to the control group in improving cervical gall swelling, irritability and irritability, dry mouth and bitter mouth, being afraid of heat and sweating, tired and tired, and sleeping and dreaming symptoms. There was significant difference in TSH between the two groups before and after treatment, but there was no significant difference between the two groups before and after treatment, and there was significant difference between the two groups after the treatment of TPOAb-TGAb. The thickness of thyroid isthmus in HT hyperthyroidism patients was significantly different between the two groups before and after treatment, but there was no significant difference between the two groups after treatment. Conclusion: Qinghuajiedu Xiaoying decoction can obviously improve the clinical symptoms of patients with heart-liver-Huowang type Hashimoto's thyroiditis, reduce the level of thyroid autoantibodies, regulate thyroid function and alleviate goitre without obvious adverse reactions. It is a safe and effective treatment.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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