犀角散加味干预HBV相关慢加急性肝衰竭的前期临床研究

发布时间：2018-05-07 18:11

本文选题：犀角散加味 + HBV(乙型肝炎病毒)　；参考：《中成药》2017年08期

【摘要】：目的探讨犀角散加味(水牛角、黄连、升麻,等)对HBV相关慢加急性肝衰竭前期的临床疗效观察。方法收集给予西医内科综合治疗75例HBV相关慢加急性肝衰竭前期患者,分为试验组与对照组,试验组在对照组基础上予犀角散加味口服,治疗1个月,观察患者症状和体征,测定丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、白蛋白(ALB)、胆碱酯酶(CHE)、凝血酶原活动度(PTA)水平,统计患者肝衰竭的发生率。结果犀角散加味治疗HBV慢加急性肝衰竭前期患者能够改善部分症状、体征,提高PTA水平,降低肝衰竭发生率,其他指标同期比较无明显差异。结论犀角散加味对HBV相关慢加急性肝衰竭前期有一定治疗作用,可能与早期阻断肝衰竭发生有关。
[Abstract]:Objective to investigate the clinical efficacy of rhino horn powder (buffalo horn, Coptis chinensis, cohosh, et al) in the early stage of HBV associated slow and acute liver failure. Methods Seventy-five patients with HBV associated slow and acute liver failure were divided into two groups: experimental group and control group. The experimental group was treated with rhino horn powder orally for 1 month, and the symptoms and signs of the patients were observed. The levels of alanine aminotransferase (alt), aspartate aminotransferase (AST), total bilirubin (TBILL), Albumin (Alb), cholinesterase (CHE) and prothrombin activity (PTAA) were measured. Results the patients with HBV slow and acute hepatic failure treated with Xuejiao Powder could improve some symptoms and signs, increase the level of PTA, and reduce the incidence of liver failure, but there was no significant difference in other indexes in the same period. Conclusion Xuejiao Powder has a certain therapeutic effect on HBV related slow and acute liver failure, which may be related to the occurrence of early block liver failure.
【作者单位】：南昌市第九医院;都昌县中医院;
【基金】：国家临床重点专科建设项目经费资助(国卫医发[2013]42号) 2014年江西省科技计划项目(20141BDH80031) 2014南昌市指导性科技计划项目(洪科发计字[2014]197号第35项)
【分类号】：R259

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