从毒邪论糖尿病大血管病变

发布时间：2018-05-16 11:24

  本文选题：糖尿病 + 血脂异常　； 参考：《辽宁中医药大学》2016年硕士论文

【摘要】：目的:探寻糖尿病大血管病变的诱发因素,为中西医临床治疗糖尿病大血管病变提供理论依据与帮助。资料与方法:收集2014年3月-2015年3月就诊于辽宁中医药大学附属医院内分泌科2型糖尿病患者210例,其中符合糖尿病大血管病变诊断标准的患者有70例设为糖尿病大血管病变组,另设70例单纯2型糖尿病(T2DM)组为对照组。收集患者的一般临床资料(年龄、性别、病程等)以及实验室指标。对比分析糖尿病并发大血管病变组患者与单纯2型糖尿病组患者在年龄、病程、糖化血红蛋白(Hb A1C)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、总胆固醇(TC)、甘油三酯(TG)、体重指数(BMI)、腰围(WC)、尿酸(UA)的差异,以此探寻糖尿病大血管病变的诱发因素。采用SPSS 17.0统计软件进行统计,组间例数比采用WPS 2016建立直方图。结果:1、糖尿病大血管病变组患者糖化血红蛋白平均值为(9.12±1.85)mmol/l,单纯2型糖尿病组平均值为(8.50±1.76)mmol/l,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05)。2、糖尿病大血管病变组患者TC平均值为(5.42±1.54)mmol/l,单纯2型糖尿病组为(4.98±0.94)mmol/l,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05);大血管病变组患者LDL-C平均值为(3.37±1.09)mmol/l,单纯2型糖尿病组为(3.05±0.72)mmol/l,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05);大血管病变组患者HDL-C平均值为(1.08±0.25)mmol/l,单纯2型糖尿病组为(1.17±0.25)mmol/l,大血管病变组低于单纯2型糖尿病组,差异具有统计学意义(P0.05);大血管病变组患者TG平均值为(2.05±0.89)mmol/l,单纯2型糖尿病组为(1.75±0.76)mmol/l,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05)。3、糖尿病大血管病变组患者血尿酸平均值为(338.20±89.63)μmol/l,单纯2型糖尿病组为(309.30±74.54)μmol/l,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05)。4、糖尿病大血管病变组患者BMI平均值为(26.01±3.87)kg/m2,单纯2型糖尿病组为(24.43±2.98)kg/m2,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.01);大血管病变组患者WC平均值为(90.91±10.41)cm,单纯2型糖尿病组为(87.03±8.50)cm,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05)。5、糖尿病大血管病变组患者年龄平均值为(60.89±9.71)岁,单纯2型糖尿病组年龄平均值为(57.37±10.32)岁,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05);糖尿病大血管病变组患者病程平均值为(10.30±3.59)年,单纯2型糖尿病组为(8.94±3.56)年,大血管病变组高于单纯2型糖尿病组,差异具有统计学意义(P0.05)。结论:1、糖尿病大血管病变与高血糖、高血脂、高尿酸、肥胖、年龄等因素相关。2、随着血糖、LDL-C、TC、TG、血尿酸的升高,年龄的增长、病程的延长糖尿病大血管病变程度加重。3、高血糖、高血脂、高尿酸、肥胖隶属于中医学痰浊、热毒等毒邪范畴,所以中医以益气养阴、解毒化瘀等方法可以防治糖尿病大血管病变。
[Abstract]:Objective: To explore the inducing factors of diabetic macroangiopathy, and to provide theoretical basis and help for the clinical treatment of diabetic macrovascular disease in Chinese and Western medicine. Data and methods: 210 patients with type 2 diabetes in Department of Endocrinology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, March 2014, which were diagnosed in the Department of Endocrinology, Liaoning University of Traditional Chinese Medicine, were in line with the diagnosis of diabetic macrovascular disease. There were 70 patients with diabetic macroangiopathy and 70 patients with type 2 diabetes mellitus (T2DM) as control group. The general clinical data (age, sex, course of disease, etc.) and laboratory indexes were collected. The age, course of disease, glycosylated blood red in patients with diabetes complicated with large vessel disease and type 2 diabetes mellitus were compared and analyzed. Protein (Hb A1C), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), total cholesterol (TC), triglyceride (TG), body mass index (BMI), waist circumference (WC), and uric acid (UA), in order to explore the inducing factors of diabetic macroangiopathy. The statistical software of SPSS 17 was used to establish a histogram compared with WPS 2016. Results: 1, sugar The mean value of glycosylated hemoglobin was (9.12 + 1.85) mmol/l in the patients with large vascular disease, and the average value of the simple type 2 diabetes group was (8.50 + 1.76) mmol/l, the large vascular lesion group was higher than that of the simple type 2 diabetes group. The difference was statistically significant (P0.05).2. The mean value of TC in the diabetic macroangiopathy group was (5.42 + 1.54) mmol/l, and the only type of diabetes alone was of type 2 diabetes. The disease group was (4.98 + 0.94) mmol/l, the large vascular lesion group was higher than the simple type 2 diabetes group, the difference was statistically significant (P0.05), the average value of LDL-C in the large vessel disease group was (3.37 + 1.09) mmol/l, the simple type 2 diabetes group was (3.05 + 0.72) mmol/l, and the large vessel disease group was higher than the only type 2 diabetes group, the difference was statistically significant (P0.05). The mean value of HDL-C in the patients with vascular disease was (1.08 + 0.25) mmol/l, the group of simple type 2 diabetes was (1.17 + 0.25) mmol/l, the group of large vessel disease was lower than that of type 2 diabetes group, the difference was statistically significant (P0.05); the mean value of TG in the group of large vessel disease was (2.05 + 0.89) mmol/l, and the group of simple type 2 diabetes mellitus was (1.75 + 0.76) mmol/l, large vascular disease. The group was higher than the simple type 2 diabetes group, the difference was statistically significant (P0.05).3, the mean value of the blood uric acid in the diabetic macroangiopathy group was (338.20 + 89.63) mu mol/l, the simple type 2 diabetes group was (309.30 + 74.54) mol/l, the large vascular disease group was higher than that of the simple type 2 diabetes group, the difference was statistically significant (P0.05).4, diabetic macroangiopathy The average value of BMI in the variable group was (26.01 + 3.87) kg/m2, the group of simple type 2 diabetes was (24.43 + 2.98) kg/m2, the large vascular lesion group was higher than that of the simple type 2 diabetes group, the difference was statistically significant (P0.01); the mean value of WC in the large vessel disease group was (90.91 + 10.41) cm, and the group of simple type 2 diabetes mellitus was (87.03 + 8.50) cm, and the large vessel lesion group was higher than pure 2. The difference was statistically significant (P0.05).5, the age average of the diabetic macroangiopathy group was (60.89 + 9.71) years, the average age of the simple type 2 diabetes group was (57.37 + 10.32) years old, the large vascular disease group was higher than the simple type 2 diabetes group, the difference was statistically significant (P0.05); the diabetic macroangiopathy group patient's disease The average range was (10.30 + 3.59) years, and the group of simple type 2 diabetes was (8.94 + 3.56) years. The large vascular disease group was higher than that of the simple type 2 diabetes group. The difference was statistically significant (P0.05). Conclusion: 1, diabetic macroangiopathy is related to hyperglycemia, hyperlipidemia, high uric acid, high uric acid, obesity, age and other factors related to.2, with the increase of blood glucose, LDL-C, TC, TG, and blood uric acid, year The growth of age, the prolongation of the course of the disease, the degree of diabetic macrovascular disease aggravates.3, hyperglycemia, hyperlipidemia, high uric acid, and obesity is subordinate to the category of phlegm and heat toxin in traditional Chinese medicine. So the Chinese medicine can prevent and cure the major vascular lesions of diabetes with the methods of nourishing qi and nourishing Yin, detoxifying and removing stasis.

【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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本文编号：1896637