健脾益气摄血法治疗慢性紫癜病的临床观察

发布时间：2018-05-18 04:08

本文选题：血小板减少 + 健脾益气摄血　；参考：《黑龙江中医药大学》2016年硕士论文

【摘要】：目的：观察健脾益气摄血法对慢性原发免疫性血小板减少症(CITP)气不摄血型患者的临床疗效,以及对外周血中T细胞亚群表达的影响,探讨脾气虚证与CITP的发病之间的关系,继而深入研究健脾益气摄血法治疗CITP作用机理。方法：筛选2015-2016年黑龙江中医药大学附属第一医院导师孙凤教授门诊就诊的证属气不摄血型CITP患者30例,作为治疗组,给予口服健脾益气方剂进行治疗,观察记录入组患者治疗前后血小板计数,中医证候积分、出血情况和T细胞亚群变化情况。结果：1.西医临床总缓解率为73.33%,治疗组治疗前、治疗后比较血小板计数上升尚可但出血情况得到明显改善有显著性差异(P0.05)；2.中医证候改善总有效率为86.66%,治疗组治疗前与治疗后比较有显著性差异(P0.05)；3.治疗组治疗前、治疗后患者外周血中表达的T细胞分别与正常对照组比较,结果均有显著性差异(P0.05)。结论：1.健脾益气摄血法治疗慢性紫癜病能明显改善患者的临床症状和出血情况,对外周血血小板计数有一定的提高。2.健脾益气摄血法通过调整T淋巴细胞数量和比值,进而可能起到调节机体免疫状态的作用。
[Abstract]:Objective: to observe the clinical effect of invigorating spleen and invigorating qi and invigorating blood in patients with chronic primary immune thrombocytopenia (CITP), and to explore the relationship between deficiency of spleen syndrome and pathogenesis of CITP, as well as the effect on the expression of T cell subsets in peripheral blood of patients with chronic immune thrombocytopenia. Then the mechanism of invigorating spleen and nourishing qi and absorbing blood to treat CITP was studied in depth. Methods: thirty outpatients with CITP with Qi non-dipping blood type were selected from the outpatient clinic of Professor Sun Feng, a tutor of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine, from 2015 to 2016. The patients were treated as the treatment group by oral prescription for invigorating spleen and supplementing qi. Platelet count, TCM syndrome score, bleeding and T cell subsets were observed before and after treatment. The result is 1: 1. The total remission rate of western medicine was 73.33. Before and after treatment, the platelet count in the treatment group was higher than that in the control group, but the bleeding situation was obviously improved. The total effective rate of TCM syndrome improvement was 86.66. There was significant difference before and after treatment in the treatment group. The expression of T cells in peripheral blood of patients in the treatment group was significantly different from that in the normal control group before and after treatment (P 0.05). Conclusion 1. The treatment of chronic purpura by invigorating spleen and invigorating qi and absorbing blood can obviously improve the clinical symptoms and bleeding of patients, and improve the platelet count of peripheral blood. The method of invigorating spleen and invigorating qi and absorbing blood may regulate the immune state of the body by adjusting the number and ratio of T lymphocytes.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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