健脾化痰、通腑泄浊法改善肥胖型2型糖尿病胰岛素抵抗临床观察

发布时间：2018-06-10 05:25

本文选题：健脾化痰 + 通腑泄浊法　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:通过临床观察,探讨健脾化痰、通腑泄浊法对肥胖型T2DM胰岛素抵抗(IR)患者的作用,观察其对肥胖型T2DM合并IR患者BMI、FPG、2hPG、FINS、HOMA-IR指数、FFA等影响,为改善肥胖型T2DM胰岛素抵抗提供有效的治疗方案。方法:本研究将60例肥胖型T2DM合并IR患者,根据症状和体征辨证为脾虚痰盛,浊毒内蕴型,随机分成治疗组和对照组各30例。对照组口服二甲双胍0.5g,一日三次;治疗组在对照组的基础上,采用健脾化痰、通腑泄浊法,方选自拟中药,疗程均为12周。12周治疗结束后,观察两组治疗前后的症状积分、BMI、血糖、血脂、HbA1c、FINS、HOMA-IR、FIB、FFA等数据,并进行统计学分析。结果:健脾化痰、通腑泄浊法联合二甲双胍对患者症状积分、BMI、血糖、血脂、HbA1c、FINS、HOMA-IR指数、FIB、FFA等均有改善作用,且优于单纯二甲双胍组。结论:通过临床观察,健脾化痰、通腑泄浊法可以改善肥胖型T2DM患者IR的现象,综合效果优于单纯使用二甲双胍组,值得进一步推广和使用。
[Abstract]:Objective: To investigate the effect of invigorating spleen and resolving phlegm, Tongfu releasing turbid method on obese T2DM insulin resistance (IR) patients through clinical observation, and observing its effect on obesity type T2DM combined with IR patients BMI, FPG, 2hPG, FINS, HOMA-IR index and FFA, so as to provide effective treatment for the improvement of obesity type T2DM insulin counteraction. Methods: 60 cases of obesity type T2DM were studied in this study. According to the symptoms and signs, according to the symptoms and signs, the syndrome of spleen deficiency phlegm and phlegm syndrome was divided into 30 cases in the treatment group and the control group, 30 cases were randomly divided into the control group and the control group. The control group was taken three times a day. On the basis of the control group, the treatment group was selected from the traditional Chinese medicine with the method of strengthening the spleen and eliminating phlegm and relieving the turbidity. The treatment course was 12 weeks after the end of the treatment and observed two after the end of the treatment of.12 weeks. The symptom integral before and after treatment, BMI, blood sugar, blood lipid, HbA1c, FINS, HOMA-IR, FIB, FFA and other data, and statistical analysis. Results: strengthening the spleen and eliminating phlegm, Tongfu turbidity method combined with metformin on the patient's symptom integral, BMI, blood sugar, blood lipid, HbA1c, FINS, HOMA-IR index, FIB, FFA and so on, and is better than the simple metformin group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong Group. Conclusion: Tong The phenomenon of IR in obese T2DM patients can be improved by clinical observation, invigorating spleen and resolving phlegm, using the method of purging the organs and relieving turbidity. The comprehensive effect is better than the simple use of metformin group. It is worth further popularization and use.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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