通脉舒络胶囊联合康复疗法治疗气虚血瘀型缺血性中风临床研究

发布时间：2018-06-15 00:13

本文选题：中风 + 气虚血瘀证　；参考：《中医学报》2017年05期

【摘要】：目的:观察通脉舒络胶囊联合康复疗法治疗气虚血瘀型缺血性中风的临床疗效。方法:选取114例气虚血瘀型缺血性中风患者,随机分为对照组和观察组,各57例。对照组采用常规药物治疗和康复治疗,观察组在此基础上联合通脉舒络胶囊,疗程为28 d,对比两组患者疗效及中医证候(主症、兼症、舌脉)改善情况,并采用美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、Fugl-Meyer(FMA)量表、日常生活活动能力量表(Barthel指数)等评价患者治疗前后功能状态改变情况,采用凝血酶原时间(prothrombin time,PT)、活化部分凝血酶时间(activated partial thromboplastin time,APTT)、血小板聚集率(platelet aggregation rate,PAR)、D-二聚体(D-Dimer,D-D)血清含量等评价患者治疗前后凝血功能改善情况。结果:观察组有效率为75.44%,明显优于对照组的56.14%,差异有统计学意义(P0.05);两组中医证候主症评分、NIHSS、FMA、Barthel指数、PT、APTT、PAR、D-D等治疗前后比较,差异均有统计学意义(P0.05)。观察组兼症评分、舌脉评分均明显低于治疗前,差异有统计学意义(P0.05),对照组兼症评分、舌脉评分治疗前后比较,差异无统计学意义(P0.05)。治疗后观察组主症评分、兼症评分、舌脉评分、NIHSS评分、PAR、D-D等均明显低于对照组,FMA、Barthel评分、PT、APTT等均明显高于对照组,差异均有统计学意义(P0.05)。结论:通脉舒络胶囊联合康复疗法用于气虚血瘀型缺血性中风患者,可改善患者血液高凝状态,减少神经缺损,提高肢体功能及日常生活能力,减轻临床症状,疗效确切。
[Abstract]:Objective: to observe the clinical effect of Tongmaisuoluo capsule combined with rehabilitation therapy on ischemic stroke of qi deficiency and blood stasis type. Methods: 114 patients with ischemic stroke of qi deficiency and blood stasis type were randomly divided into control group and observation group, 57 cases each. The control group was treated with routine medicine and rehabilitation, and the observation group was treated with Tongmaisuoluo capsule for 28 days. The curative effect of the two groups and the improvement of TCM syndromes (main symptoms, syndromes, tongue veins) were compared. The National institute of health stroke scale (NIH) and the activity of Daily living scale (ADL) were used to evaluate the changes of functional status before and after treatment. Prothrombin time (PT), activated partial thrombin time (partial thromboplastin), activated partial thromboplastin time (APTTT), platelet aggregation rate (platelet aggregation rate) and serum content of D-dimer D-Dimer (D-Dimer) D-D) were used to evaluate the improvement of coagulation function before and after treatment. Results: the effective rate of the observation group was 75.44, which was significantly better than that of the control group (56.14), the difference was statistically significant (P0.05), and the difference between the two groups was statistically significant before and after treatment with NIHSS-FMA-Barthel index, PTAPTTTT-PARD-D and so on. The scores of syndromes and tongue veins in the observation group were significantly lower than those before treatment, and the difference was statistically significant (P 0.05). There was no significant difference between the control group and the control group before and after treatment (P 0.05). After treatment, the scores of main symptoms, syndromes, tongue vein and NIHSS scores were significantly lower in the observation group than those in the control group (P 0.05), and were significantly lower than those in the control group (P 0.05). Conclusion: Tongmaisuluo capsule combined with rehabilitation therapy can improve blood hypercoagulability, reduce nerve defect, improve limb function and daily life ability, and alleviate clinical symptoms in patients with ischemic apoplexy of Qi deficiency and blood stasis type.
【作者单位】：河南中医药大学第一附属医院;
【基金】：国家中医药管理局全国名老中医药专家传承工作室建设项目{豫中医业函[2014]86号} 河南省高等学校重点科研项目(16A320074)
【分类号】：R255.2

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