2型糖尿病血瘀证血细胞参数与微血管并发症发生的临床相关性研究
发布时间：2018-07-17 15:14
【摘要】：目的:本研究通过观察患者的相关临床指标,探究2型糖尿病血瘀证型微血管并发症的发生与血细胞参数之间的关系。为2型糖尿病血瘀证的辨证提供客观指标,并提供早期预防、治疗糖尿病及微血管并发症的思路。材料与方法:选用与纳入标准相符的2型糖尿病血瘀证患者178例,依据排除标准及剔除标准除去19例,最终研究病例159例。以是否存在微血管并发症的发生为依据进行分组,即微血管并发症组和无并发症组。搜集并记录患者的基本情况,如性别、年龄、病程。入院后第一次的血常规(红细胞压积、红细胞平均体积、红细胞分布宽度、血小板计数、血小板压积、血小板平均体积)。选用SPSS17.0软件进行统计解析,计数资料采用X2检验,计量资料采用单因素方差分析检验。进行初步相关性分析。结果:1.在收集的159个病例中,微血管并发症组与无并发症组相对照,两组年龄、病程有差异(P0.05),具有可比性;性别无差异(P0.05)。2.在红细胞参数方面,微血管并发症组红细胞压积(HCT)较高,与无并发症组相对照,具有统计学意义(P0.05);红细胞平均体积(MCV)、红细胞分布宽度(RDW)均比无并发症组高,且差异具有统计学意义(P0.05)。3.在血小板参数方面,微血管并发症组的血小板计数(PLT)和血小板压积(PCT)较无并发症组降低,但两者相比较没有统计学差异(P0.05);并发症组的血小板平均体积(MPV)与无并发症组相比较有所升高,且具有统计学意义(P0.05)。结论:1.2型糖尿病血瘀证微血管并发症的发生与年龄、病程相关联;与性别无关联。2.2型糖尿病血瘀证微血管并发症的发生与红细胞压积、红细胞平均体积、红细胞分布宽度具有相关性。3.2型糖尿病血瘀证微血管并发症的发生与血小板平均体积有关;与血小板压积、血小板计数无关联。
[Abstract]:Objective: to investigate the relationship between blood cell parameters and microvascular complications in type 2 diabetes mellitus. To provide objective indexes for differentiation of blood stasis syndrome in type 2 diabetes mellitus, and to provide early prevention and treatment of diabetes mellitus and microvascular complications. Materials and methods: 178 cases of type 2 diabetes mellitus with blood stasis syndrome were selected according to the inclusion criteria. 19 cases were removed according to the exclusion criteria and the exclusion criteria. 159 cases were finally studied. According to the occurrence of microvascular complications, they were divided into two groups: microvascular complication group and no complication group. Collect and record the patient's basic information, such as gender, age, course of disease. The first blood routine after admission (hematocrit, mean erythrocyte volume, erythrocyte distribution width, platelet count, platelet hematocrit, mean platelet volume). SPSS 17.0 software was used for statistical analysis, X2 test was used for counting data, and single factor analysis of variance test was used for measurement data. Preliminary correlation analysis was carried out. The result is 1: 1. In 159 cases collected, microvascular complications group and no complications group compared, the two groups of age, course of disease were different (P0.05), comparable; gender no difference (P0.05). 2. In terms of erythrocyte parameters, hematocrit (HCT) in microvascular complication group was higher than that in no complication group (P0.05), mean erythrocyte volume (MCV) and erythrocyte distribution width (RDW) were higher than those in no complication group. The difference was statistically significant (P0.05). Platelet count (PLT) and platelet pressure-product (PCT) in microvascular complications group were lower than those in non-complication group. However, there was no statistical difference between the two groups (P0.05); the mean platelet volume (MPV) in the complication group was higher than that in the non-complication group (P0.05). Conclusion the occurrence of microvascular complications in type 1.2 diabetes mellitus with blood stasis syndrome is related to age and course of disease, and there is no correlation between microvascular complications and hematocrit and mean volume of erythrocyte in type 2.2 diabetes mellitus with blood stasis syndrome. The occurrence of microvascular complications in type 3.2 diabetic blood stasis syndrome was related to the mean volume of platelets, but not to platelet compactness and platelet count.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
，
本文编号：2130064
[Abstract]:Objective: to investigate the relationship between blood cell parameters and microvascular complications in type 2 diabetes mellitus. To provide objective indexes for differentiation of blood stasis syndrome in type 2 diabetes mellitus, and to provide early prevention and treatment of diabetes mellitus and microvascular complications. Materials and methods: 178 cases of type 2 diabetes mellitus with blood stasis syndrome were selected according to the inclusion criteria. 19 cases were removed according to the exclusion criteria and the exclusion criteria. 159 cases were finally studied. According to the occurrence of microvascular complications, they were divided into two groups: microvascular complication group and no complication group. Collect and record the patient's basic information, such as gender, age, course of disease. The first blood routine after admission (hematocrit, mean erythrocyte volume, erythrocyte distribution width, platelet count, platelet hematocrit, mean platelet volume). SPSS 17.0 software was used for statistical analysis, X2 test was used for counting data, and single factor analysis of variance test was used for measurement data. Preliminary correlation analysis was carried out. The result is 1: 1. In 159 cases collected, microvascular complications group and no complications group compared, the two groups of age, course of disease were different (P0.05), comparable; gender no difference (P0.05). 2. In terms of erythrocyte parameters, hematocrit (HCT) in microvascular complication group was higher than that in no complication group (P0.05), mean erythrocyte volume (MCV) and erythrocyte distribution width (RDW) were higher than those in no complication group. The difference was statistically significant (P0.05). Platelet count (PLT) and platelet pressure-product (PCT) in microvascular complications group were lower than those in non-complication group. However, there was no statistical difference between the two groups (P0.05); the mean platelet volume (MPV) in the complication group was higher than that in the non-complication group (P0.05). Conclusion the occurrence of microvascular complications in type 1.2 diabetes mellitus with blood stasis syndrome is related to age and course of disease, and there is no correlation between microvascular complications and hematocrit and mean volume of erythrocyte in type 2.2 diabetes mellitus with blood stasis syndrome. The occurrence of microvascular complications in type 3.2 diabetic blood stasis syndrome was related to the mean volume of platelets, but not to platelet compactness and platelet count.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
，
本文编号：2130064
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