养阴清热消瘿方治疗甲状腺功能亢进症阴虚火旺证的临床疗效观察
发布时间：2018-07-21 11:58
【摘要】：目的：本研究通过观察养阴清热消瘿方治疗甲状腺功能亢进症阴虚火旺证,明确该方的疗效和安全性,为治疗该病提供有效方药。方法：将符合纳入标准的阴虚火旺证甲亢患者60例按1:1平行对照原则分为治疗组和对照组,每组30例。治疗组给予养阴清热消瘿方,每日一剂,分早晚两次服用。对照组给予甲巯咪唑(他巴唑)5～10mg,每日3次。两组均以4周为1个疗程,观察3疗程。观察治疗前后证候积分,甲状腺激素(TT3、TT4、FT3、FT4、TSH)及相关抗体(TRAb)甲状腺B超等指标变化,进行疗效的判定和评估。结果：①两组病人的性别、年龄、病程基线值进行组间均衡性比较,无显著性差异(P0.05)。治疗前中医证候积分、实验室相关检测指标组间均衡性比较,无显著性差异(P0.05)。②在中医证候疗效方面,两组患者证候积分比较,两者均有明显改善,差异有统计学意义(P0.05)。③两组治疗后TT3、TT4、FT3、FT4均见显著下降(P0.05),而且治疗组下降的幅度优于对照组,两组之间进行比较,具有统计学意义(P0.05)。④两组治疗后TRAb均见显著下降(P0.05),而且治疗组下降的幅度优于对照组,具有统计学意义。⑤两组治疗后甲状腺肿大均有一定程度的改善,前后比较,有显著性差异(P0.05)。⑥两组治疗后指颤方面明显减轻,有显著性差异(P0.05)。组间比较,在无指颤和中度指颤明显减少方面治疗组疗效显著优于对照组,经统计学分析,P0.05,有明显差异。⑦安全性：两组肝肾功能检查均为’见异常,对照组有5例出现白细胞减少经常规治疗恢复正常。两组其余均未见其他不良反应结论：养阴清热消瘿方用于治疗甲状腺功能亢进症阴虚火旺证,可以改善患者的临床症状和证候积分,调节甲状腺激素水平和甲状腺相关抗体,减慢心率,改善甲状腺肿大,并且无肝肾功能损害。从研究结果可以初步判定,养阴清热消瘿方与口服西药相比,治疗甲状腺功能亢进阴虚火旺证更明显优势,临床疗效明显,安全又有效,值得临床上推广应用。
[Abstract]:Objective: to observe the effect and safety of Yangyin Qingre Xiaoying recipe in treating hyperthyroidism with Yin deficiency and fire and hyperthyroidism, and to provide effective prescription for the treatment of hyperthyroidism. Methods: sixty patients with hyperthyroidism of yin deficiency and fire hyperthyroidism were divided into treatment group (30 cases) and control group (30 cases) according to the principle of parallel control at 1:1. The treatment group was given Yangyin Qingre Xiaoying prescription, one dose daily, two times in the morning and evening. The control group was treated with methimazole (methimazole) of 10 mg, 3 times a day. In both groups, 4 weeks were used as a course of treatment, and 3 courses of treatment were observed. The changes of syndromes score, thyroid hormone (TT3TSH) and related antibody (TRAB) were observed before and after treatment, and the curative effect was evaluated. Results there was no significant difference in sex, age and course of disease baseline between the two groups (P0.05). There was no significant difference between the two groups before treatment (P0.05) in the curative effect of TCM syndromes, the two groups had significant improvement in the syndromes integral, both of which were significantly improved, and the scores of TCM syndromes were not significantly different between the two groups before treatment, and there was no significant difference between the two groups (P0.05). The difference was statistically significant (P0.05). 3 after treatment, TT _ 3H _ 3T _ 4T _ 3H _ 3FT _ 4 decreased significantly in both groups (P0.05), and the extent of decrease in the treatment group was better than that in the control group, which was compared between the two groups. There was statistical significance (P0.05) .4 TRAB decreased significantly after treatment in both groups (P0.05), and the extent of decrease in the treatment group was better than that in the control group, and there was a certain degree of improvement in thyroid enlargement after treatment in the two groups with statistical significance (P0.05), and there was no significant difference between the two groups before and after treatment. There was significant difference (P0.05) .6 the two groups after treatment significantly alleviated finger fibrillation, there was a significant difference (P0.05). The efficacy of the treatment group was significantly better than that of the control group in the aspect of no finger fibrillation and moderate finger fibrillation reduction. There was a significant difference in safety between the two groups (P 0.05). The liver and kidney function of the two groups were abnormal. In the control group, 5 cases had leukopenia and returned to normal after routine treatment. Conclusion: Yangyin Qingre Xiaoying prescription can improve the clinical symptoms and syndromes of patients with hyperthyroidism, regulate the level of thyroid hormone and thyroid-related antibodies, and improve the clinical symptoms and syndromes of patients with hyperthyroidism. Slow heart rate, improve goitre, and no damage to liver and kidney function. From the results of the study, it can be preliminarily determined that compared with oral western medicine, Yangyin Qingre Xiaoying prescription has more obvious advantages in treating hyperthyroidism with Yin deficiency and fire and flourishing syndrome. The clinical curative effect is obvious, and it is safe and effective. It is worth popularizing and applying in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2135452
[Abstract]:Objective: to observe the effect and safety of Yangyin Qingre Xiaoying recipe in treating hyperthyroidism with Yin deficiency and fire and hyperthyroidism, and to provide effective prescription for the treatment of hyperthyroidism. Methods: sixty patients with hyperthyroidism of yin deficiency and fire hyperthyroidism were divided into treatment group (30 cases) and control group (30 cases) according to the principle of parallel control at 1:1. The treatment group was given Yangyin Qingre Xiaoying prescription, one dose daily, two times in the morning and evening. The control group was treated with methimazole (methimazole) of 10 mg, 3 times a day. In both groups, 4 weeks were used as a course of treatment, and 3 courses of treatment were observed. The changes of syndromes score, thyroid hormone (TT3TSH) and related antibody (TRAB) were observed before and after treatment, and the curative effect was evaluated. Results there was no significant difference in sex, age and course of disease baseline between the two groups (P0.05). There was no significant difference between the two groups before treatment (P0.05) in the curative effect of TCM syndromes, the two groups had significant improvement in the syndromes integral, both of which were significantly improved, and the scores of TCM syndromes were not significantly different between the two groups before treatment, and there was no significant difference between the two groups (P0.05). The difference was statistically significant (P0.05). 3 after treatment, TT _ 3H _ 3T _ 4T _ 3H _ 3FT _ 4 decreased significantly in both groups (P0.05), and the extent of decrease in the treatment group was better than that in the control group, which was compared between the two groups. There was statistical significance (P0.05) .4 TRAB decreased significantly after treatment in both groups (P0.05), and the extent of decrease in the treatment group was better than that in the control group, and there was a certain degree of improvement in thyroid enlargement after treatment in the two groups with statistical significance (P0.05), and there was no significant difference between the two groups before and after treatment. There was significant difference (P0.05) .6 the two groups after treatment significantly alleviated finger fibrillation, there was a significant difference (P0.05). The efficacy of the treatment group was significantly better than that of the control group in the aspect of no finger fibrillation and moderate finger fibrillation reduction. There was a significant difference in safety between the two groups (P 0.05). The liver and kidney function of the two groups were abnormal. In the control group, 5 cases had leukopenia and returned to normal after routine treatment. Conclusion: Yangyin Qingre Xiaoying prescription can improve the clinical symptoms and syndromes of patients with hyperthyroidism, regulate the level of thyroid hormone and thyroid-related antibodies, and improve the clinical symptoms and syndromes of patients with hyperthyroidism. Slow heart rate, improve goitre, and no damage to liver and kidney function. From the results of the study, it can be preliminarily determined that compared with oral western medicine, Yangyin Qingre Xiaoying prescription has more obvious advantages in treating hyperthyroidism with Yin deficiency and fire and flourishing syndrome. The clinical curative effect is obvious, and it is safe and effective. It is worth popularizing and applying in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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