乳腺癌中医肝郁痰凝证型与性激素受体相关性的Meta分析

发布时间：2018-08-14 10:19

【摘要】：目的系统评价乳腺癌中医肝郁痰凝证型与性激素受体的关系。方法计算机全面检索乳腺癌中医证型与性激素受体相关性的中文文献,检索日期截止至2014年7月27日,由2位研究者独立对纳入研究文献进行方法学质量评价,并进行资料提取,采用Rev Man4.2软件对乳腺癌肝郁痰凝证型与性激素受体的关系进行Meta分析。结果共5篇文献符合纳入标准。Meta分析结果显示乳腺癌中医肝郁痰凝证型与其他证型相比,雌激素受体(ER)的表达具有统计学差异(P0.05),假设检验Z=2.12,P0.05,合并OR值2.52,95%置信区间(CI)为(1.07~5.94)。孕激素受体(PR)表达情况趋势与ER表达情况一致,但差别无统计学意义(P0.05)。结论乳腺癌中医辨证分型中肝郁痰凝证型与ER表达相关。但由于纳入研究质量所限,尚需开展更多高质量的研究。
[Abstract]:Objective to evaluate the relationship between the type of liver stagnation and phlegm coagulation syndrome and sex hormone receptor in breast cancer. Methods Chinese literature on relationship between TCM syndromes of breast cancer and sex hormone receptor was searched by computer. The retrieval date was up to July 27, 2014. Two researchers independently evaluated the methodological quality of the literature included in the study. The data were extracted and the relationship between the type of liver stagnation and phlegm coagulation in breast cancer and sex hormone receptor was analyzed by Meta with Rev Man4.2 software. Results according with the inclusion criteria, Meta-analysis showed that the expression of estrogen receptor (ER) in breast cancer patients with liver stagnation and phlegm coagulation syndrome was significantly different from that of other syndrome types (P0.05). The results showed that the expression of estrogen receptor (ER) in breast cancer patients was significantly different from that of other syndrome types (P0.05). The results showed that the expression of estrogen receptor (ER) was significantly higher than that of other syndrome types (P0.05). The trend of progesterone receptor (PR) expression was consistent with ER expression, but the difference was not statistically significant (P0.05). Conclusion the type of liver stagnation and phlegm coagulation is related to ER expression in TCM syndrome differentiation of breast cancer. However, due to the limitation of research quality, more high-quality research is needed.
【作者单位】：河北省中医院;
【基金】：国家自然科学基金资助项目(No.81603412) 河北省中医药管理局科研计划项目(No.2015104;2017163) 中央高校基本科研业务费专项资金资助(No.216113119)
【分类号】：R273

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