治疗冠心病方剂用药规律的数据挖掘研究

发布时间：2018-08-27 14:12

【摘要】：目的对治疗冠心病中药复方进行数据挖掘,研究其方剂用药规律。希望对临床研发冠心病中药新药有所裨益。方法提取1985年9月至2015年7月国家专利数据库中治疗冠心病的263项中药复方专利并建立数据库,运用中医传承辅助系统软件(V2.5),采用关联规则、复杂网络、熵方法分析等技术挖掘中药复方的方剂用药规律。结果提取出治疗冠心病的263项中药复方专利中,最多有30味药,最少1味药,平均(6.20±6.10)味药。最常见的治则为活血化瘀(87次,33.08%);最常见的单药为丹参(143次,54.40%)等;最常见的对药为丹参-川芎(62次,23.57%)等;最常见的角药为丹参-川芎-红花(33次,12.55%)等。基于关联规则发现常见药物组合有:桃仁→红花(置信度0.844),降香→丹参(置信度0.794),红花+赤芍→川芎(置信度1),川芎+桃仁→红花(置信度0.952)。基于复杂网络发现的核心药物有:丹参、三七、红花、当归、川芎、甘草、黄芪、麦冬;通过熵方法提取出的新方组合有:木香、苏合香、安息香、樟脑、薄荷、高良姜、白芍、陈皮、鸡内金、北沙参。结论本研究揭示了治疗冠心病的中药复方专利的核心用药和方剂用药规律,为临床用药提供指导。
[Abstract]:Objective to study the regularity of traditional Chinese medicine prescription for coronary heart disease (CHD). It is hoped that it will benefit clinical research and development of new Chinese medicine for coronary heart disease. Methods from September 1985 to July 2015, 263 Chinese medicine compound patents were extracted from the national patent database for treating coronary heart disease, and the database was established. The software of traditional Chinese Medicine inheritance Assistant system (V2.5) was used, association rules and complex network were used. Entropy analysis and other techniques were used to excavate the law of prescriptions of traditional Chinese medicine compound. Results out of 263 patents of TCM compound for coronary heart disease, there were at most 30 herbs and at least 1 medicine, with an average of (6.20 卤6.10). The most common drug was Salvia miltiorrhiza (54.40%), Salvia miltiorrhiza Rhizoma Chuanxiong (62 times, 23.57%), Salvia miltiorrhiza Rhizoma Chuanxiong (33 times, 12.55%) and so on, the most common treatment was promoting blood circulation and removing blood stasis (87 times), the most common single drug was Salvia miltiorrhiza (143 times) 54.40%, the most common drug was Salvia miltiorrhiza Chuanxiong (23.57%) and so on. Based on association rules, common drug combinations were found as follows: Peach kernel safflower (confidence 0.844), Rhizoma Salvia miltiorrhiza (confidence 0.794), Carthamus rubra Rhizoma Chuanxiong (confidence 1), Ligusticum chuanxiong Rhizoma Prunus Bunge (confidence 0.952). The core drugs found on the basis of the complex network are: Salvia miltiorrhiza, Panax notoginseng, safflower, Angelica sinensis, Ligusticum chuanxiong, liquorice, astragalus, Ophiopogonis japonicus, and the new prescription combination extracted by entropy method: Amur, Scutellaria, benzoin, camphor, menthol, alpinia officinalis, Radix Paeoniae Alba, Old Peel, Chicken Neijin, Radix Corydae Ginseng. Conclusion this study revealed the core drug and prescriptions of TCM compound patent for coronary heart disease, and provided guidance for clinical use.
【作者单位】：中国中医科学院广安门医院;北京中医药大学;
【基金】：国家自然科学基金资助项目(No.81202803) 中央公益性科研院所基本科研业务费专项资金项目(No.ZZ0908023)
【分类号】：R259

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