三黄煎剂改善乳腺癌患者慢性应激状态30例临床研究

发布时间：2018-10-05 07:34

【摘要】：目的探讨三黄煎剂干预乳腺癌患者慢性应激状态的临床功效。方法将30例绝经后雌激素受体阳性乳腺癌患者随机分为治疗组与对照组,每组病例数各15例。对照组口服内分泌治疗,治疗组在原主治方案基础上加用三黄煎剂口服,每日一剂,3个月为1个周期,连续观察2个周期;两组患者每月观察记录应激症状积分、治疗前后分别检测血清氧化应激指标一氧化氮(NO)、超氧化歧化酶(SOD)、总抗氧化能力(T-AOC)含量。结果 2月后,治疗组应激症状积分较对照组具有显著差异(P0.01),6月后,应激积分降至3.03分,完全缓解应激状态;6月后,对照组患者血清氧化应激指标较治疗前NO上升,血清抗氧化指标SOD水平及T-AOC水平较治疗前稍有下降,提示机体处于慢性应激状态;治疗组血清NO明显降低,显著低于治疗前及对照组(P0.05);而血清SOD水平及T-AOC水平呈明显上升,高于治疗前及对照组,各指标均优于对照组(P=0.02或0.01)。结论三黄煎剂可有效改善绝经后乳腺癌慢性应激状态,对乳腺癌内分泌治疗疗效与控制复发转移起到一定的辅助干预作用。
[Abstract]:Objective to investigate the clinical effect of Sanhuang decoction on chronic stress state of breast cancer patients. Methods Thirty patients with postmenopausal estrogen receptor positive breast cancer were randomly divided into treatment group and control group with 15 cases in each group. The control group was treated by oral endocrine therapy, the treatment group was treated with Sanhuang decoction on the basis of the original main treatment plan, once a day for one cycle for 3 months, and two consecutive cycles were observed, and the stress symptom scores were recorded monthly in the two groups. Total antioxidant capacity (T-AOC) of nitric oxide (NO),) superoxide dismutase (SOD),) was measured before and after treatment. Results after 2 months, the scores of stress symptoms in the treatment group were significantly higher than those in the control group (P0.01). After 6 months, the stress score decreased to 3.03, which completely alleviated the stress state, and after 6 months, the serum oxidative stress index of the control group was higher than that of the control group (P0.01). The levels of serum antioxidant index SOD and T-AOC were slightly lower than those before treatment, suggesting that the body was in chronic stress state, the serum NO in the treatment group was significantly lower than that in the treatment group and the control group (P0.05), while the serum SOD and T-AOC levels were significantly increased in the treatment group. Higher than before treatment and control group, each index is superior to the control group (P0. 02 or 0. 01). Conclusion Sanhuang decoction can effectively improve the chronic stress state of postmenopausal breast cancer and play an auxiliary role in endocrine treatment of breast cancer and control of recurrence and metastasis.
【作者单位】：南京中医药大学附属医院;
【基金】：江苏省中医院高峰学术人才培养(y2014cr06) 2015年中韩合作项目(313) 江苏高校优势学科建设工程资助项目(012062003010)
【分类号】：R273

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