中医五种治疗模式对大肠癌患者症状改善作用差异性的临床研究

发布时间：2018-10-29 22:04

【摘要】：目的：研究中医五种治疗模式对大肠癌患者症状改善作用的差异性。材料与方法：回顾性分析2015年3月至2016年3月于辽宁中医药大学附属医院肿瘤科住院治疗的大肠癌患者的临床资料,建立患者临床资料数据库,根据纳入标准及排除标准进行筛选,最后有221例患者纳入研究,并分为与西医抗肿瘤治疗结合的中医巩固组(无癌)、防护组(足量化疗)、加载组(减量化疗)、维持组(化疗有效后,观察)和单纯中医治疗组。运用SPSS 17.0统计软件,采用配对t检验和卡方检验,统计分析5组患者治疗后的症状改善情况。结果：1、221例大肠癌患者经过中医药治疗后,乏力、气短、大便异常(包括便秘、大便稀溏、便血)、疼痛、恶心呕吐、食欲减退、失眠等症状积分均有显著改善(P0.05)。其中,乏力症状经治疗后的改善率最高,为74.88%,其次为食欲减退,70.37%,便血症状的改善率最低,为28.57%,其他症状经治疗后的改善率在54%-64%之间。2、5组大肠癌患者的症状经过治疗后均有不同程度的改善,其症状平均积分与治疗前相比较均明显下降(P0.01);在症状治疗有效率方面,中医药配合西医抗肿瘤治疗的两组相比,防护组有效率明显高于加载组(90.91%vs68.63%,P0.05);西医抗肿瘤治疗之后的两组对比,巩固组有效率明显高于维持组(80.52%vs64.52%,P0.05);单纯中医治疗组有效率为22%,明显低于前4组(P0.05)。结论：1、中医药治疗可以明显改善大肠癌患者的临床症状。2、中医药治疗大肠癌的症状疗效,与有无肿瘤及肿瘤进展程度、有无化疗及化疗强度有关,五种治疗模式可以不同程度地提高与其相对应的大肠癌患者的症状疗效。
[Abstract]:Objective: to study the difference of symptom improvement in patients with colorectal cancer by five treatment modes of traditional Chinese medicine (TCM). Materials and methods: the clinical data of colorectal cancer patients hospitalized in Department of Oncology, affiliated Hospital of Liaoning University of traditional Chinese Medicine from March 2015 to March 2016 were analyzed retrospectively. According to the inclusion criteria and exclusion criteria, 221 patients were included in the study. They were divided into three groups: the Chinese medicine consolidation group (without cancer), the protective group (adequate chemotherapy), the loading group (reducing chemotherapy). Maintenance group (after chemotherapy, observation) and traditional Chinese medicine treatment group. Using SPSS 17.0 statistical software, paired t test and chi-square test were used to analyze the improvement of symptoms after treatment in 5 groups. Results: the scores of fatigue, shortness of breath, abnormal stool (including constipation, loose stool, bloody stool), pain, nausea and vomiting, loss of appetite and insomnia were significantly improved in 1221 patients with colorectal cancer after treatment with traditional Chinese medicine (P0.05). Among them, the improvement rate of symptoms of fatigue after treatment was the highest (74.88), followed by anorexia, 70.37, and the improvement rate of hematochezia was the lowest (28.57). The improvement rate of other symptoms after treatment was between 54% and 64%. After treatment, the symptoms of all the patients with colorectal cancer were improved to some extent, and the mean score of symptoms decreased significantly (P0.01). In terms of the effective rate of symptomatic treatment, the effective rate of the protection group was significantly higher than that of the loading group (90.91 vs 68.63 P 0.05). After anti-tumor therapy, the effective rate of consolidation group was significantly higher than that of maintenance group (80.52 vs 64.52, P0.05); the effective rate of traditional Chinese medicine treatment group was 22, significantly lower than that of the first four groups (P0.05). Conclusion: 1. Chinese medicine treatment can obviously improve the clinical symptoms of patients with colorectal cancer. 2. The effect of TCM treatment on the symptoms of colorectal cancer is related to the degree of tumor and tumor progression, the degree of chemotherapy and the intensity of chemotherapy. Five treatment modes can improve the symptomatic efficacy of colorectal cancer patients in varying degrees.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R273

【参考文献】