蝉芩颗粒对感染后咳嗽患者气道神经源性炎症影响

发布时间：2018-10-30 12:47

【摘要】：目的:以感染后咳嗽风邪恋肺证患者为研究对象,采用前瞻、随机、平行对照的临床研究方法,比较两组证候指标、莱彻斯特咳嗽量表(LCQ)积分、诱导痰中SP值的差异。以此证实蝉芩颗粒在感染后咳嗽治疗中存在新的作用机制,为中医风邪恋肺的病机与气道神经源性炎症内在联系提供理论基础,为防治感染后咳嗽提供新的思路与方法。方法:选择上海中医药大学附属曙光医院传统中医科、呼吸科门诊感染后咳嗽风邪恋肺证患者119例。随机分为蝉芩颗粒组61例和惠菲宁组58例,疗程为2周。通过比较两组咳嗽证候指标、LCQ量表测评、诱导痰中SP值的差异。观察蝉芩颗粒对感染后咳嗽患者咳嗽症状、生活质量、神经源性炎症的干预作用。结果:蝉芩颗粒在咳嗽症状疗效评分上与惠菲宁对照组比较,差异有统计学意义(P0.001),疗效优于惠菲宁对照组。蝉芩颗粒组LCQ总积分上高于惠菲宁组,疗效优于惠菲宁对照组(P0.05)。两组患者疾病疗效评价比较,差异具有统计学意义(P0.001),蝉芩颗粒组疗效优于惠菲宁对照组。蝉芩颗粒组和惠菲宁组诱导痰中SP值与治疗前进行自身前后比较,差异有统计学意义(P0.001),但两组间差异无统计学意义(P=0.957)。结论:蝉芩颗粒可有效改善感染后咳嗽患者的症状,改善生活质量,减轻神经源性炎症,疗效肯定。
[Abstract]:Objective: to compare the difference of syndrome index, (LCQ) integral of Leicester cough scale and SP value in induced phlegm between two groups by prospective, random and parallel control clinical study. It is proved that there is a new mechanism in the treatment of cough after infection, which provides a theoretical basis for the internal relationship between the pathogenesis of wind evil and lung and airway neurogenic inflammation, and provides a new way of thinking and method for the prevention and treatment of post-infection cough. Methods: 119 patients with cough, wind evil and lung syndrome were selected from Department of traditional Chinese Medicine, Shuguang Hospital affiliated to Shanghai University of traditional Chinese Medicine. The patients were randomly divided into two groups: cicadin granule group (n = 61) and Huifining group (n = 58). The course of treatment was 2 weeks. The differences of SP in induced sputum were compared between the two groups by comparing the indexes of cough syndrome and LCQ scale. To observe the effect of Cichang granule on cough symptom, quality of life and neurogenic inflammation in patients with cough after infection. Results: compared with Huifining control group, there was a significant difference in cough symptom score between Cichang granule and Huifining control group (P0.001), and the curative effect was better than that of Huifining control group. The total LCQ score in Cichang granule group was higher than that in Huifining group, and the curative effect was better than that in Huifining control group (P0.05). The difference between the two groups was statistically significant (P0.001). The curative effect of Cichang Qinling granule group was better than that of Huifining control group. The SP value of induced sputum in Cichang granule group and Huifining group was significantly different from that before and after treatment (P0. 001), but there was no significant difference between the two groups (P0. 957). Conclusion: cicalin granule can effectively improve the symptoms of cough patients after infection, improve the quality of life, reduce neurogenic inflammation, the curative effect is positive.
【作者单位】：上海中医药大学附属曙光医院;上海中医药研究院特色诊疗技术研究所;上海中医药大学曙光临床医学院;
【基金】：上海市卫生局科研课题(201314113)
【分类号】：R259

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