温肾通络止痛方治疗肾阳虚原发性骨质疏松症的处方优化研究

发布时间：2018-11-10 08:38

【摘要】：目的：观测温肾通络止痛方三方对肾阳虚原发性骨质疏松症(Osteoporosis, OP)的治疗效果,筛选出最佳的处方。方法：本研究采用随机对照的原则,选择符合纳入标准的肾阳虚型原发性骨质疏松患者32例,随机分为温肾通络止痛方治疗组A(A方8例)、治疗组B(B方8例)、治疗组C(C方8例)及对照组(8例),3个治疗组分别予温肾通络止痛方治疗,对照组采用基础治疗,4组治疗时间均为2个月,对4组治疗前、治疗1月,2月的临床症状及骨密度进行数理统计分析,以观察疗效并筛选出最优处方。结果：治疗1月后温肾通络止痛方A组有效率62.5%,治疗组B有效率75%,治疗组C有效率87.5%,明显优于对照组有效率37.5%,比较组间差异有统计学意义。治疗2月后治疗组A显效率0%、有效率100%,治疗组B显效率37.5%,有效率100%,治疗组C显效率12.5%、有效率100%,明显优于对照组显效率0%,有效率75%,组间比较有显著差异。治疗组B显效率明显优于治疗组A和C。4组治疗后,腰脊疼痛、腰膝酸软无力、畏寒肢冷、下肢抽筋、步履艰难等症状均有好转,临床症状积分明显下降,且治疗2月后治疗组A、B、C与对照组相比有统计学差异(P0.05),治疗组B与A、C比较有统计学差异(P0.05),明显较优,治疗前后骨密度改变无统计学意义(P0.05),治疗前后血、尿、粪常规、肝肾功能、心电图等安全性指标未见明显异常,各组用药后未见明显不良反应。结论：温肾通络止痛方B治疗肾阳虚原发性骨质疏松症疗效更显,能维持骨密度,改善临床症状,无不良反应,能有效防治肾阳虚型骨质疏松症。
[Abstract]:Objective: to observe the therapeutic effect of Wenshen Tongluo Zhitong recipe on (Osteoporosis, OP) of primary osteoporosis due to deficiency of kidney-yang. Methods: in this study, 32 patients with primary osteoporosis of kidney-yang deficiency type were randomly divided into two groups: A (A prescription (n = 8) and B (B prescription (n = 8). The treatment group (8 cases) and the control group (8 cases) were treated with Wenshen Tongluo Zhitong recipe, the control group was treated with basic treatment, the 4 groups were treated for 2 months, and the 4 groups were treated for 1 month before treatment. The clinical symptoms and bone mineral density in 2 months were analyzed by mathematical statistics to observe the curative effect and to select the best prescription. Results: after one month of treatment, the effective rate of Wenshen Tongluo Zhitong Fang (group A) was 62.5, the effective rate of treatment group B was 75, and the effective rate of treatment group C was 87.5, which was obviously better than that of control group (37.5%). The difference between the two groups was statistically significant. After two months of treatment, the treatment group showed an effective rate 0 and an effective rate of 100. The treatment group B showed an effective rate of 37.5 and the effective rate was 100. The treatment group C showed an effective rate of 12.5 and the effective rate was 100. The effective rate was 100, which was obviously better than that of the control group. The markedly effective rate was 0, and the effective rate was 75. There were significant differences between groups. The effective rate of treatment group B was obviously better than that of group A and group C.4 after treatment, the pain of lumbar spine, weakness of waist and knee, chills of cold limbs, cramps of lower limbs, and treadmill were all improved, and the clinical symptom score was obviously decreased. After 2 months of treatment, there was a statistical difference between the treatment group and the control group (P0.05), and the treatment group B and Agna C had statistical difference (P0.05), which was significantly better than that of the control group (P0.05), and the treatment group B was significantly better than the control group (P0.05). Before and after treatment there was no significant change in bone mineral density (P0.05). Before and after treatment blood urine fecal routine liver and kidney function electrocardiogram and other safety indicators were not significantly abnormal. Conclusion: Wenshen Tongluo Zhitong recipe B is more effective in the treatment of primary osteoporosis due to deficiency of kidney yang. It can maintain bone mineral density, improve clinical symptoms, have no adverse reactions, and can effectively prevent and treat osteoporosis of kidney yang deficiency type.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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