养心定悸汤治疗气血亏虚型心脏神经症的临床疗效观察

发布时间：2019-03-11 20:14

【摘要】：目的观察养心定悸汤治疗60例气血亏虚型心脏神经症患者的中医证候、早搏、焦虑及抑郁的临床疗效。方法选择符合条件的心脏神经症患者共60例,试验采用随机对照方法,治疗组、对照组按1：1分配。治疗组给予养心定悸汤治疗,每日一剂,水煎取汁300m1,分早、晚2次口服。对照组给予谷维素20mg日3次口服,观察治疗前后两组患者中医证侯疗效、早搏疗效、HAMA及HAMD量表变化。疗程均为4周。结果中医证候疗效总有效率97%,对照组总有效76.7%,经统计学处理,P0.01,具有统计学意义,说明治疗组在疗效上优于对照组。早搏疗效上治疗组总有效率76.9%,对照组总有效率46.1%,经统计学处理,P0.05,具有统计学意义,治疗组在改善患者早搏疗效上优于对照组。改善焦虑及抑郁疗效评价：治疗组在HAMA减分率上总有效率80%,对照组总有效率80%,经统计学处理,P0.05,无统计学意义,治疗组在改善患者焦虑疗效上与对照组无明显差异。治疗组在HAMD减分率上总有效率97%,对照组在HAMD减分率上总有效率76.7%,经统计学处理,P0.01,具有统计学意义,治疗组在改善患者抑郁疗效上明显优于对照组,具有显著性差异。且治疗组在治疗过程中无明显不良反应。结论养心定悸汤可明显改善气血亏虚型心脏神经症患者的中医证候、早搏情况、抑郁状况,对于患者的焦虑状态上与谷维素疗效相当。患者于用药期间未产生明显不良反应。
[Abstract]:Objective to observe the clinical efficacy of Yangxin Dingxu decoction in treating 60 cases of cardiac neurosis with deficiency of qi and blood, such as syndrome of TCM, premature beat, anxiety and depression. Methods A total of 60 patients with cardiac neurosis were randomly divided into two groups: treatment group (n = 60) and control group (n = 10). The treatment group was treated with Yangxin Dingxu decoction, one dose per day, water decoction 300ml, oral twice in the morning and late. The patients in the control group were treated with glutamine 20 mg / d for 3 times. The curative effect of TCM syndrome, the curative effect of premature beat, the changes of HAMA and HAMD scale before and after treatment were observed in the two groups. The course of treatment was 4 weeks. Results the total effective rate of TCM syndrome was 97%, and the total effective rate of control group was 76.7%. After statistical treatment, P0.01 had statistical significance, which indicated that the therapeutic effect of the treatment group was better than that of the control group. The total effective rate was 76.9% in the treatment group and 46.1% in the control group. The treatment group was superior to the control group in improving the curative effect of premature beat. Evaluation of the efficacy of improving anxiety and depression: the total effective rate was 80% in the treatment group and 80% in the control group on the reduction rate of HAMA. There was no statistical difference between the treatment group and the control group (P 0.05). There was no significant difference between the treatment group and the control group in the improvement of anxiety. The total effective rate was 97% in the treatment group and 76.7% in the HAMD reduction rate in the treatment group and in the control group, the total effective rate in the treatment group was 76.7% on the reduction rate of HAMD. After statistical treatment, P0.01 had statistical significance. The treatment group was obviously superior to the control group in improving the depressive effect of the patients. There was a significant difference between the two groups. There were no obvious adverse reactions in the treatment group. Conclusion Yangxin Dingxu decoction can obviously improve the TCM syndrome, premature beat and depression of the patients with qi-blood deficiency cardiac neurosis. The curative effect of Yangxin Dingxu decoction on the anxiety state of the patients is similar to that of glutamine. There was no significant adverse reaction during the medication.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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