基于数据挖掘的平乐郭氏传统药物治疗骨性关节炎的用药规律研究

发布时间：2019-07-03 15:17

【摘要】：目的探讨平乐郭氏正骨传统制剂治疗骨性关节炎的用药规律。方法收集整理平乐郭氏传统药物治疗骨性关节炎处方,借助数据挖掘技术探讨平乐郭氏传统药物治疗骨性关节炎的用药规律。结果 882首方剂中,使用频次在50次及以上的药物有30味,使用频次前3位的分别是牛膝、当归、白芍。按药物组合出现频次大于120次由高到低排序,前3为分别是"牛膝、甘草""牛膝、当归""当归、白芍"。共挖掘12个核心组合。结论平乐正骨治疗骨性关节炎多用活血化瘀药、补血药、补气药、祛风湿散寒药等,治法主要是补益肝肾、活血化瘀。牛膝、当归、白芍、甘草、杜仲、川芎、独活、熟地、乳香、没药是平乐郭氏正骨治疗骨关节炎常用的核心药物。
[Abstract]:Objective to investigate the regularity of traditional preparation of Pingle Guo Zhenggu in the treatment of osteoarthritis. Methods the prescription of Pingle Guo's traditional drugs in the treatment of osteoarthritis was collected and sorted out, and the regularity of Pingle Guo's traditional drugs in the treatment of osteoarthritis was discussed with the help of data mining technology. Results among the 882 prescription, 30 drugs were used 50 times or more, and the first three drugs were Achyranthes bidentata, Angelica sinensis and Paeonia lactiflora. According to the frequency of drug combination, the frequency of occurrence was more than 120 times from high to low, the first three were "Achyranthes bidentata, Glycyrrhiza uralensis Fisch", "Achyranthes bidentata", "Angelica sinensis, Paeonia lactiflora". A total of 12 core combinations were excavated. Conclusion Pingle Zhenggu in the treatment of osteoarthritis is mainly treated with promoting blood circulation and removing blood stasis, tonifying blood, tonifying qi, dispelling wind dampness and dispersing cold medicine, etc. The main treatment method is to replenish liver and kidney, promote blood circulation and remove blood stasis. Achyranthes bidentata, Radix Paeoniae Rubra, Glycyrrhiza uralensis Fisch, Eucommia ulmoides, Ligusticum chuanxiong, Dufu, cooked ground, frankincense and myrrh are the core drugs commonly used in the treatment of osteoarthritis.
【作者单位】：河南省洛阳正骨医院(河南省骨科医院);
【基金】：2014年度河南省中医药科学研究专项课题(No.2014ZY02072) 全国中药特色技术传承人才培训项目(国中医药人教函〔2015〕168号) 2015年度河南省中医药科学研究专项课题(No.2015ZY02064)
【分类号】：R274.9

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