应用SPECT对说谎状态下脑功能区的研究—听觉刺激下大脑功能区的改变

发布时间：2018-02-05 00:34

本文关键词： 局部脑血流发射型计算机测谎 ECD SPM　出处：《中国医科大学》2010年硕士论文　论文类型：学位论文

【摘要】： 前言在司法实践中,犯罪嫌疑人(被告人)的供述、当事人的陈述以及证人证言等主观证据缺少相应证据链条证明时,通过测谎技术来证明这些主观证据是否真实可信是至关重要的。但由于目前的测谎技术主要依靠多道生理记录仪,根据心电、血压、呼吸、皮肤电阻等植物神经反应的生理指标间接判定被检者是否说谎,存在假阳性或假阴性结果,其测试结果在司法诉讼中不能作为鉴定结论直接应用。因此,确定在说谎状态下大脑功能区的改变对今后解决测谎问题起着重要作用。 SPECT是用其具有专门探测核射线的探头,探测体内放射性物质(核素药物99mTc)的分布状况来进行检查,可以观察大脑在思维活动时的功能区变化状况。本研究通过对15名受试者进行SPECT脑功能扫描,进而研究其在说谎与说真话状态下脑功能区改变的不同,旨在分析说谎状态下的神经网络。试验对象与方法一、试验对象 15名健康志愿者,均为右利手,男性,年龄23-28岁。所有受检者均无精神与神经系统疾病及相关病史。志愿者均在详细了解本研究目的、内容及步骤后自愿接受检查。二、试验方法 15名被试者每人共测3次(即静息状态下扫描,说真话状态下扫描与说谎状态下扫描),分3天进行。每次在注药后进行ECT扫描,同时提问问题。问题：你母亲姓什么?回答：如姓“李”(说真话)或姓“张”(说假话)。试验完毕后进行确认。具体步骤如下： 1、第一次(静息状态下扫描) 被试者建立静脉通道,身体放松仰卧在扫描床上。让被试者闭目休息,消除杂虑。静息5分钟开始注药,并进行ECT扫描。 2、第二次(说真话状态下扫描) 被试者建立静脉通道,身体放松仰卧在扫描床上。让被试者闭目休息,消除杂虑。静息5分钟开始注药,并进行ECT扫描,同时提问问题。被试者即刻回答(说真话)问题。 3、第三次(说谎状态下扫描) 被试者建立静脉通道,身体放松仰卧在扫描床上。让被试者闭目休息,消除杂虑。静息5分钟开始注药,并进行ECT扫描,同时提问问题。被试者即刻回答(说假话)问题。三、参数设计采集矩阵：128×128,能峰：140keV,窗宽：±20%。采集模式：ZOOM：1.45,探头各旋转1800,5.6／帧,每帧采集25s,共采集64帧影像,采集时间共约需30min。统计学处理——SPM分析：本研究采用SPM2 (SPM2, Wollcome Department of Cognitive Neurology, London, UK)分析脑功能区变化。分析过程包括图像转化、图像标准化、统计学分析和显著性评估4个主要步骤。通过SPM2软件将所有SPECT横断面图像转换成analysis7格式,在MATLAB6.1平台上,应用SPM2对图像进行处理和数据分析。首先,按SPM程序内自带的SPECT模板进行图像归一化处理,以平均局部脑血流55ml／100ml／min水平进行归一化,得到调整过的脑功能区激活图像,使之与Talairach的空间坐标对应。我们将调整过的数据进行比较,即可得到一系列由数值构成的t统计参数图SPM{t},(体素差异阈值设定为10),然后将SPM{t}图转换成标准正态分布的Z参数图SPM{Z},SPM{Z}上的每一个显著差异均是通过对数据进行t检验(p=0.05)来评估的。再根据Talairach图谱投射到相应的大脑区域,即得到说谎时大脑的激活区。结果在说谎状态下枕回、岛叶、中颞叶、额中回、扣带前回、海马及小脑的放射性分布明显升高。结论确认说谎的脑功能区为枕回、岛叶、中颞叶、额中回、扣带前回、海马及小脑。
[Abstract]:Preface
In judicial practice, criminal suspects (the defendant)'s testimony, statements of the parties and witness testimony and other evidence of the lack of corresponding subjective evidence chain that, through the polygraph test to prove the subjective evidence is authentic is critical. But because of the polygraph technology currently rely mainly on the polygraph, according to ECG, blood pressure, breathing skin resistance and other physiological indexes, the autonomic responses were seized indirectly determine whether there lies, false positive or false negative results, the test results in judicial proceedings can not be directly used as conclusions. Therefore, to determine the brain function in the area lying under the change in the future to solve the problem of lie detection plays an important role.
SPECT is used to detect the distribution of radioactive substances in the body (nuclide drug 99mTc) with its special probe to detect nuclear radiation. It can observe the changes of the brain in the functional area when thinking.
In this study, 15 subjects were scanned by SPECT brain function, and then studied the difference of brain functional areas in lying and telling the truth, aiming at analyzing the neural network under the condition of lying.
Test object and method
First, the test object
15 healthy volunteers were all right-handed men. The age of the male was 23-28 years old. All the subjects had no mental and neurological diseases or related medical history. Volunteers volunteered to know the purpose, contents and steps of the study.
Two, test method
15 subjects were measured 3 times per person (i.e. resting state scan, said scanning and lying truth under scanning), conducted in 3 days. Every time after injection ECT scan, and ask questions. Question: your mother's surname what? Answer: as the name "Li" (to tell the truth) or Zhang (lie). The test was confirmed after the specific steps are as follows:
1, first (resting state scan)
The subjects set up the venous channel, the body relaxed on the scan bed. Let the subjects close their eyes and eliminate miscellaneous concerns. Take 5 minutes to start the drug injection and carry out a ECT scan.
2, second times (when the truth is scanned)
The subjects set up venous access, and their body relaxed and supine on the scanning bed. Let subjects closed their eyes and rest to eliminate miscellaneous concerns. After 5 minutes of rest, drug injection was started, and ECT scan was performed. Meanwhile, questions were asked.
3, third (scans in the state of lying)
The subjects set up the venous channel, and the body relaxed and supine on the scanning bed. Let the subjects shut their eyes to rest and eliminate miscellaneous concerns. After 5 minutes of rest, drug injection was started, and ECT scan was performed. Meanwhile, questions were asked. Subjects answered questions immediately. (three) parameter design.
Collection: 128 * 128 matrix, the peak: 140keV, window width: + 20%. acquisition mode: ZOOM:1.45, probe the rotation of 1800,5.6 / frames, each frame acquisition 25s, were collected from 64 images, a total acquisition time is about SPM analysis of 30min. statistical analysis: This study adopts SPM2 (SPM2, Wollcome Department of Cognitive Neurology London, UK), analysis of the changes of brain function area. The analysis process including image conversion, image normalization, statistical analysis and significant assessment of 4 main steps. Through the SPM2 software will be all SPECT cross-sectional images into analysis7 format on the MATLAB6.1 platform, using SPM2 for image processing and data analysis. Firstly, according to the the SPM program included in the SPECT template image is normalized, normalized to the average local cerebral blood flow of 55ml / 100ml / min levels, activation of brain function area image adjustment, and make the Talairach The space coordinates. We compare the adjusted data can be obtained by a series of numerical components of the T statistical parameter map SPM{t} (voxel difference threshold value is 10), then convert SPM{t} drawings into Z parameter map SPM{Z} standard normal distribution, a significant difference is SPM{Z} the t test was performed on the data (p=0.05) to evaluate. According to the Talairach map projected onto the corresponding brain regions, to obtain the activation areas of the brain. When lying
Result
The radiological distribution of the hippocampus and cerebellum was significantly increased in the occipital gyrus, the insula, the middle temporal lobe, the middle frontal gyrus, the anterior cingulate gyrus, and the cerebellum.
conclusion
It is confirmed that the brain function area of lying is occipital gyrus, insula, meso temporal lobe, middle frontal gyrus, anterior cingulate gyrus, hippocampus and cerebellum.

【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：D918.2

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