图片再认ERP在重型颅脑损伤后记忆障碍鉴定的应用

发布时间：2018-04-05 22:01

本文选题：法医临床学　切入点：重型颅脑损伤　出处：《中国法医学杂志》2009年02期

【摘要】：目的探讨图片再认事件相关电位(ERP)对重型颅脑损伤(sTBI)后记忆障碍法医学鉴定的应用价值。方法采用韦氏记忆量表(WMS-RC)和Neuroscan ERP仪,对74例健康志愿者(对照组)及需评定精神伤残等级的29例重型颅脑损伤后记忆障碍者(sTBI组)进行记忆能力和图片再认ERP检测。结果sTBI组WMS-RC各分测验量表分及记忆商数(MQ)均值均明显低于对照组(P0.01);完成ERP任务的反应时、正确率明显延长和降低(P0.01)。对照组在靶与非靶刺激呈现后170ms和500ms左右均可记录到潜伏期无显著性差异的二个正向波(P170和P500),但靶刺激诱发的P500波幅明显高于非靶刺激(P0.01);sTBI组可记录到相似的ERP波形,但各成分的波幅、潜伏期均明显降低和延长(P0.01)。sTBI组P500潜伏期与WMS-RC的记图、再认、再生分测验量表分和MQ值均呈高度负相关(r=-0.73～-0.83,P0.01),而与伤残等级呈明显正相关(r=0.65,P0.01)。结论图片再认诱发的P500潜伏期与WMS-RC反映的短时记忆功能及鉴定的精神伤残等级明显相关,可为sTBI后记忆障碍的伤残鉴定提供一项较客观的神经电生理依据。
[Abstract]:Objective to investigate the value of image recognition event related potentials (ERP) in forensic identification of memory disorders after severe craniocerebral injury (TBI).Methods 74 healthy volunteers (control group) and 29 severe craniocerebral injury patients with memory impairment were assessed by WMS RCC and Neuroscan ERP.Results the mean values of WMS-RC scores and memory quotient (MQ) in sTBI group were significantly lower than those in control group (P 0.01), and the correct rate was significantly prolonged and decreased when ERP task was completed.In the control group, 170ms and 500ms showed no significant difference in latency between target and non-target stimuli, but the amplitude of P500 wave induced by target stimulation was significantly higher than that of non-target stimulation (P0.01) and similar ERP waveform could be recorded in the control group.Conclusion the P500 latency induced by image recognition is significantly correlated with the short-term memory function reflected by WMS-RC and the rating of mental disability, which may provide an objective basis for the identification of memory impairment after sTBI.
【作者单位】：华中科技大学同济医学院法医学系;同济医学院附属同济医院儿科;
【分类号】：D919.4

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