高强度聚焦超声沿螺旋路径连续扫描产生组织损伤的建模与实验研究

发布时间：2018-05-11 02:20

  本文选题：高强度聚焦超声 + 组织损伤　； 参考：《南京大学》2017年硕士论文

【摘要】：高强度聚焦超声(HIFU)在肿瘤治疗的临床应用上取得了飞速进展,而HIFU换能器的扫描模式对HIFU治疗的热损伤形成有着重要的影响。本文通过理论模拟和实验探究,研究HIFU在采用螺旋线路径的连续扫描模式下温度场的分布和组织损伤形成情况。理论方面,建立了基于KZK方程和Pennes生物传热方程的声热耦合模型以及基于热剂量的损伤形成模型,定量预测HIFU治疗的温度场分布和损伤形成状况。实验方面,进行了以凝胶和离体牛肝组织样品的HIFU实验,设定扫描速度和螺旋路径的栅格间距为控制变量来对比损伤情况,分析了栅格间距和扫描速度对温度场分布,损伤形状以及治疗效率的影响。研究结果表明,采用螺旋路径的连续扫描模式,可以充分发挥热扩散效应的积极作用,有效产生完全覆盖治疗区域的均匀性损伤。选择栅格间距较小的螺旋路径,更能发挥热扩散的作用力,更容易实现损伤对治疗区域的完全覆盖,获得更高的治疗效率。本文的研究工作对于HIFU治疗安全性和治疗效率的提高具有指导意义。
[Abstract]:High intensity focused ultrasound (HIFU) has made rapid progress in the clinical application of tumor therapy, and the scanning mode of HIFU transducer has an important effect on the formation of thermal injury in HIFU treatment. In this paper, the distribution of temperature field and the formation of tissue damage in HIFU under the continuous scanning mode with helical path are studied by theoretical simulation and experimental investigation. In theory, the acoustothermal coupling model based on KZK equation and Pennes bio-heat transfer equation and the damage formation model based on thermal dose were established to quantitatively predict the temperature field distribution and injury formation of HIFU therapy. In the aspect of experiment, the HIFU experiments of gel and in vitro bovine liver tissue samples were carried out. The scanning speed and the space between the helical paths were set as the control variables to compare the damage, and the distribution of the temperature field between the grid spacing and the scanning velocity was analyzed. The effects of injury shape and therapeutic efficiency. The results show that continuous scanning mode with spiral path can give full play to the positive effect of thermal diffusion and effectively produce uniform damage covering the treatment area completely. The helical path with small grid spacing can play the role of thermal diffusion more easily to achieve the complete coverage of the treatment area and obtain higher therapeutic efficiency. The research in this paper is of guiding significance for the improvement of safety and efficiency of HIFU treatment.
【学位授予单位】：南京大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R454.3;TB559
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本文编号：1871984