三区带模拟移动床分离邻香兰素与香兰素

发布时间：2018-11-23 18:46

【摘要】：建立了同步及异步的三区带模拟移动床(SMB)分离邻香兰素和香兰素的数学模型,并通过实验成功实现了二者的高纯度、高效率分离.首先确定了SMB系统的流动相为V(乙醇)∶V(水)=35∶65,固定相为反相C18硅胶.通过单组分前沿分析法测定了邻香兰素和香兰素在反相C18制备柱上的吸附等温线,通过经验公式分别计算了二者的总传质系数与轴向扩散系数,依据线性驱动力模型建立了SMB及Varicol模型.限定邻香兰素和香兰素的纯度都高于99.5%,洗脱液流量为2.0mL/min,运用复合型法最大化进料流量,之后对优化结果进行实验验证.优化得到SMB分离系统的最大处理量为0.481mL/min,在此优化条件下实验得到邻香兰素和香兰素的纯度分别为99.3%和99.0%;优化得到Varicol分离系统最大处理量为0.551mL/min,与SMB系统相比提高了14.6%,实验得到邻香兰素和香兰素的纯度分别为99.2%和99.1%.
[Abstract]:A mathematical model for the separation of vanillin and vanillin by synchronous and asynchronous three-zone simulated moving bed (SMB) was established, and the high purity and high efficiency separation of the two were successfully achieved by experiments. The mobile phase of SMB system is V (ethanol): V (water) = 35: 65, and the stationary phase is reversed-phase C18 silica gel. The adsorption isotherms of o-vanillin and vanillin on reversed C18 column were determined by one-component frontier analysis. The total mass transfer coefficient and axial diffusion coefficient were calculated by empirical formula. According to the linear driving force model, the SMB and Varicol models are established. The purity of o-vanillin and vanillin is higher than 99.5, the flow rate of eluant is 2.0 mL / min, the compound method is used to maximize the feed flow rate, and the optimized results are verified by experiments. The maximum processing capacity of SMB separation system was 0.481mL / min. Under the optimized conditions, the purity of o-vanillin and vanillin were 99.3% and 99.0%, respectively. The maximum processing capacity of the Varicol separation system was 0.551mL / min, which increased 14.6% compared with the SMB system. The purity of vanillin and vanillin were 99.2% and 99.1%, respectively.
【作者单位】：厦门大学化学化工学院;
【基金】：厦门市科技计划项目(3502Z20143008)
【分类号】：TQ028;TQ655

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