有氧运动对中老年肥胖人群减脂效果及与UCP2基因敏感性关联研究

发布时间：2018-04-19 03:10

本文选题：有氧运动 + 减脂　；参考：《山东体育学院》2017年硕士论文

【摘要】：目的:通过研究12周有氧运动对单纯性肥胖中老年人的体重、腰围、腰臀比、BMI、体脂%等体成分体形态指标、血脂系列参数、脂肪细胞因子的影响,并进一步探究有氧运动与济南市单纯性肥胖中老年人解偶联蛋白2基因第四外显子处A55V基因多态性的关联性,为中老年人制定个性化的减肥运动处方提供实践和理论依据。方法:本研究选取济南市槐荫区单纯性肥胖中老年人80名,随机分为实验组和对照组。通过双能X射线等测定人体的形态学指标,通过分子生物学技术测试人体的各项血液指标,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法检测受试人群的UCP2基因第四外显子处A55V基因多态性,通过统计学分析方法(SPSS)分析各项指标在实验前后的变化及组间是否具有统计学意义。结果:(1)经过12周的有氧运动,实验组中各组的体重、BMI、腰围、腰臀比较实验前均有显著性下降;总体组与肥胖组的体脂%也显著性降低。(2)经过12周的有氧运动,总体组和肥胖组的总胆固醇和低密度脂蛋白胆固醇均有显著性降低,高密度脂蛋白胆固醇有上升的趋势但变化不明显;总体组和肥胖组的脂联素有显著性升高;总体组、肥胖组及超重组的游离脂肪酸均有显著性降低。(3)经过12周的有氧运动,通过对实验组总体和肥胖组的研究发现,AV基因型受试者的形态学指标(BMI、腰围、腰臀比、体重、体脂%)及血液指标(游离脂肪酸、总胆固醇)均具有显著性降低,脂联素水平具有显著性增高。结论:(1)12周的有氧运动可以有效降低中老年肥胖超重人群的形态指标及血液指标(高密度脂蛋白胆固醇和脂联素除外),有氧运动是中老年肥胖人群减肥减脂的有效健身方法。(2)三种基因型受试者的形态指标及血液指标在实验前后具有显著性差异,但AV基因型受试者在实验后各指标的变化较AA、VV基因型明显,因此AV基因型可以考虑作为运动减脂的遗传基因标记。
[Abstract]:Objective: to study the effects of 12 weeks aerobic exercise on body weight, waist circumference, waist-to-hip ratio (WHR), body fat%, body mass fraction, lipid series parameters and adipocytic cytokines in elderly patients with simple obesity.Furthermore, the relationship between aerobic exercise and A55V polymorphism in the fourth exon of the uncoupling protein 2 gene in the elderly with simple obesity in Jinan City was explored, which provided practical and theoretical basis for the establishment of individualized exercise prescription for weight loss in middle-aged and elderly people.Methods: in this study, 80 middle and old people with simple obesity in Huayin District of Jinan City were randomly divided into two groups: experimental group and control group.The morphological indexes of the human body were measured by dual-energy X-ray, and the blood indexes of the human body were measured by the molecular biology technique.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect A55V gene polymorphism in exon 4 of UCP2 gene.SPSS was used to analyze the changes of the indexes before and after the experiment and whether there was statistical significance between groups.Results (1) after 12 weeks of aerobic exercise, the body weight, waist circumference and waist-hip ratio of each group in the experimental group were significantly decreased before the experiment, and the body fat% of the total group and the obese group were also significantly decreased after 12 weeks of aerobic exercise.The total cholesterol and low density lipoprotein cholesterol in the whole group and the obese group were significantly decreased, the high density lipoprotein cholesterol had an upward trend but the change was not obvious; the adiponectin level in the total group and the obese group was significantly increased; in the overall group, there was a significant increase in adiponectin.After 12 weeks of aerobic exercise, it was found that the morphologic indexes of AV genotypes were BMIs, waist-circumference, waist-to-hip ratio, body weight, and so on, after 12 weeks of aerobic exercise.The blood index (free fatty acid, total cholesterol) and adiponectin level were significantly decreased and adiponectin level was significantly increased.Conclusion aerobic exercise for 12 weeks can effectively reduce the morphologic and blood indexes (except HDL cholesterol and adiponectin) in overweight and middle-aged obese people. Aerobic exercise is an effective method to reduce weight and fat in middle-aged and old obese people.The morphological and blood indexes of the three genotypes were significantly different before and after the experiment.However, the changes of AV genotypes were more obvious than those of AAV genotypes, so AV genotypes could be considered as genetic markers of exercise lipid reduction.
【学位授予单位】：山东体育学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：G804.2

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