间歇低氧结合运动对IR大鼠血清及股四头肌抗氧化能力的影响

发布时间：2018-04-25 13:15

本文选题：胰岛素抵抗 + 大鼠　；参考：《上海体育学院学报》2017年01期

【摘要】：目的:探讨间歇性低氧暴露结合有氧运动对胰岛素抵抗(IR)大鼠的抗氧化能力的影响。方法:选择健康普食大鼠12只设为普食常氧安静组(NNC),将高脂诱导的胰岛素抵抗大鼠分为常氧安静组(NC)、低氧安静组(HC)、常氧运动组(NE)和低氧运动组(HE),并进行4周的间歇低氧和跑台运动干预。结果:1与NC组比较,3个干预组血清的T-AOC、SOD和GSH-Px均升高且具有统计学意义,MDA均下降且具有统计学意义;3个干预组股四头肌的MDA均下降且具有统计学意义,HC组的GSH-Px升高且具有统计学意义,NE组和HE组的T-AOC、SOD和GSH-Px均升高且具有统计学意义。2与NNC组比较,3个干预组的血清SOD均升高且具有统计学意义,NE组和HE组的血清GSH-Px均升高且具有统计学意义;HC组股四头肌的M DA降低具有统计学意义,NE组股四头肌的SOD升高有统计学意义,HE组的股四头肌MDA降低和GSH-Px升高均具有统计学意义。结论:间歇低氧、运动和间歇低氧结合运动均可改善高脂饲料诱导IR大鼠血液和股四头肌的抗氧化能力,其中以间歇低氧结合运动组效果最好。
[Abstract]:Aim: to investigate the effects of intermittent hypoxic exposure combined with aerobic exercise on the antioxidant capacity of insulin resistance (IRR) rats. Methods: twelve normal diet rats were divided into four groups: normoxic normoxic group (normoxic exercise group) and hypoxic exercise group (normoxic exercise group). The rats with insulin resistance induced by hyperlipidemia were divided into three groups: normoxic quiet group, hypoxic quiet group, normoxic exercise group and hypoxic exercise group, and the rats were divided into three groups: normoxic normoxic exercise group, normoxic exercise group and normoxic exercise group. Hypoxia and treadmill exercise intervention. Results compared with NC group, the serum T-AOCnsSOD and GSH-Px of the three intervention groups were increased, and the MDA of the quadriceps femoris of the three intervention groups were all decreased and the GSH-Px of HC group was significantly higher than that of the NC group, and that of the three intervention groups was significantly lower than that of the NC group, and that of the three intervention groups was significantly lower than that of the NC group. Moreover, the T-AOCn SOD and GSH-Px of NE group and HE group were significantly higher than that of NNC group. The serum SOD of three intervention groups were all increased, and the serum GSH-Px of NE group and HE group were all increased and had statistical significance. The decrease of MDA of quadriceps femoris in HC group was statistically significant. The increase of SOD in quadriceps femoris in NE group was significantly higher than that in HE group. The decrease of MDA and the increase of GSH-Px in HE group were statistically significant. Conclusion: intermittent hypoxia, exercise and intermittent hypoxia combined exercise can improve the antioxidant ability of IR rats' blood and quadriceps femoris induced by high fat diet, especially in intermittent hypoxia combined exercise group.
【作者单位】：中山大学南方学院体育教育中心;韶关学院体育学院;广州体育学院运动与健康系;
【分类号】：G804.7

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