运动性心脏重塑:microRNA的调节

发布时间：2018-05-04 17:01

本文选题：运动 + 心脏重塑　；参考：《体育科学》2017年11期

【摘要】：长期适宜强度的运动训练可诱导心脏重塑,主要表现为促进心肌细胞肥大和增殖、细胞存活、心肌血管再生、抑制心肌间质纤维化等一系列结构重塑,心脏产生适应性增大。虽已有较多研究探讨运动性心脏重塑的发生机制,但其至今尚不十分清楚。近年,研究人员通过基因芯片技术获得了运动性心脏重塑发生过程miRNA的表达图谱,部分研究通过功能获得和缺失方法进一步确认了关键miRNA,为研究运动性心脏重塑的调控机制提供了新的视角。另外,miRNA在运动性心脏重塑和病理性心脏重塑发生过程中表现出明显不同的变化特点,为运动性心脏重塑属生理性而非病理性重塑的阐释提供了新的证据。深入分析miRNA在运动性心脏重塑过程中的变化规律和作用机制,可为应用miRNA预防和治疗心脏疾病提供新的方法和策略。
[Abstract]:Long-term exercise training with appropriate intensity can induce cardiac remodeling, which can promote cardiac myocyte hypertrophy and proliferation, cell survival, myocardial vascular regeneration, inhibition of myocardial interstitial fibrosis and a series of structural remodeling. Although more studies have been done to explore the mechanism of cardiac remodeling, it is still unclear. In recent years, researchers have used gene chip technology to obtain miRNA expression patterns during exercise induced heart remodeling. In some studies, the key miRNAs were further identified by functional acquisition and deletion methods, which provided a new perspective for the study of the regulatory mechanism of cardiac remodeling induced by exercise. In addition, miRNA showed different characteristics in the process of exercise heart remodeling and pathological heart remodeling, which provided new evidence for the explanation that exercise heart remodeling belongs to physiological rather than pathological remodeling. Further analysis of the changes and mechanism of miRNA in the process of exercise heart remodeling may provide a new method and strategy for the prevention and treatment of cardiac diseases with miRNA.
【作者单位】：湖南工业大学体育学院;国家体育总局体育科学研究所;
【基金】：国家体育总局体育科学研究所基本科研业务经费(15-37)
【分类号】：G804.2

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