体力活动与多种类型癌症发生风险相关性及其可能机制研究进展

发布时间：2018-05-12 02:00

本文选题：体力活动 + 癌症　；参考：《体育科学》2017年09期

【摘要】：癌症已经成为全世界第2大死亡诱因。研究表明,欧洲9%~19%的癌症发生率归因于体力活动不足。为了降低癌症风险,生活习惯干预(体力活动增加)可能成为一种经济且长期有效的癌症控制措施。通过在Pubmed和Highwire等网站中检索关键词"physical activity"、"leisure-time physical activity"、"exercise"、"cancer"、"risk"、"mechanism"和"biological changes"等关键词,分析相关文献,对体力活动/运动和癌症风险之间关系以及体力活动/运动影响致癌作用的可能机制进行综述,以期为推广和提倡通过增加体力活动来预防癌症和增进健康生活方式提供理论支持。研究结果:1.无论肥胖与否,体力活动增加与多种类型癌症发生风险降低相关。2.体力活动降低癌症风险的最可能生化机制包括直接抗癌机制和间接抗癌机制,直接抗癌机制包括:代谢类激素、表观遗传学影响、氧化应激、免疫力、慢性炎症等,间接抗癌机制包括:体重降低和雌激素、脂肪因子、维生素D和阳光暴露、心理上幸福感等。研究结论:1)建议将体力活动增加作为预防癌症风险的一种有效干预措施;2)体力活动通过直接抗癌机制和间接抗癌机制降低多种癌症发生风险。
[Abstract]:Cancer has become the second leading cause of death in the world. Studies show that nine out of nine cancers in Europe are attributable to inadequate physical activity. To reduce cancer risk, lifestyle intervention (increased physical activity) may be an economic and long-term effective cancer control measure. By retrieving the keywords "physical activity", "leisure-time physical activity", "exercise", "cancer", "risk", "mechanism" and "biological changes" in Pubmed and Highwire websites, the authors analyzed the relevant literature and reviewed the relationship between physical activity / exercise and cancer risk, as well as the possible mechanisms of physical activity / exercise affecting carcinogenesis. In order to promote and promote physical activity to prevent cancer and promote healthy lifestyles. The result of the study was: 1. Whether obese or not, increased physical activity is associated with a reduced risk of multiple types of cancer. The most likely biochemical mechanisms for physical activity to reduce cancer risk include direct and indirect anticancer mechanisms, including metabolic hormones, epigenetic effects, oxidative stress, immunity, chronic inflammation, etc. Indirect anti-cancer mechanisms include weight loss and estrogen, fat factors, vitamin D and sun exposure, psychological well-being, and so on. Conclusion 1) it is suggested that physical activity increase as an effective intervention to prevent cancer risk. Physical activity can reduce the risk of many kinds of cancer through direct and indirect anticancer mechanisms.
【作者单位】：四川大学体育学院;成都大学体育学院;沈阳工业大学体育部;国家体育总局运动医学研究所;
【分类号】：G804.2

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