肌力康复训练对老年人衰老性肌萎缩干预功效的研究

发布时间：2018-06-12 06:19

本文选题：衰老性肌萎缩 + 肌力康复训练　；参考：《武汉体育学院》2017年硕士论文

【摘要】：研究目的衰老性肌萎缩不仅是指骨骼肌质量下降,也包括肌肉机能逐渐下降,力量下降、最大收缩速度下降以及收缩和舒张普遍变慢。在我国人口老年化的背景下,老年人群发生跟衰老性相关的疾病呈日益增长的趋势,其中关于衰老性肌萎缩的深入研究和治疗方法已成为一个具有潜在威胁的问题,并越来越会引起重视。但选取合适的预防衰老性肌萎缩的干预方案依然是有待解决的问题。因此,研究出切实可行的训练方案对干预老年人肌萎缩有着非常重要的意义。研究方法本研究对象选自武汉市紫阳湖敬老院中15名患有衰老性肌萎缩的老年人,其中男性8人,女性7人。以EWGSOP(欧洲老年人衰老性肌萎缩研究团队)发布的标准为依据,进行身体机能指标测试和生化血液指标的采集,身体机能指标包括:握力(男子"f30kg,女子"f20kg)、骨骼肌质量(男子"f10.76 kg/m2,女子"f6.76kg/m2)和4米步速(男/女"f1 m/s),生化血液指标包括:超氧化物歧化酶(SOD)、胰岛素生长因子-1(IGF-1)、肌肉生长抑制素(MSTN)、肿瘤坏死因子α(TNF-α)。通过进行12周的肌力康复训练,比较肌力康复训练对衰老性肌萎缩患者的身体机能指标及生化血液指标的影响效果,为衰老性肌萎缩患者制定科学合理的运动方案奠定基础。结果:(1)通过12周的肌力康复训练后,对比男性老年人干预前后的身体机能指标,表现为:干预后的男性老年人握力显著大于干预前(P0.01);干预后男性老年人四米步速显著高于干预前(P0.01);而干预后男性老年人骨骼肌质量指数SMI与干预前无显著性差异(P0.05)。(2)通过12周的肌力康复训练后,对比男性老年人干预前后的血液指标,表现为:干预后男性老年人胰岛素样生长因子-1(IGF-1)无显著性差异(P0.05),干预后男性老年人肌肉生长抑制素(MSTN)、肿瘤坏死因子α(TNF-α)均显著低于干预前(P0.01,P0.05),干预后男性老年人超氧化物歧化酶(SOD)显著高于干预前(P0.01)。(3)通过12周的肌力康复训练后,对比女性老年人干预前后的身体机能指标,表现为:干预后的女性老年人握力显著大于干预前(P0.01);干预后女性老年人四米步速显著高于干预前(P0.01);而干预后女性老年人骨骼肌质量指数SMI与干预前无显著性差异(P0.05)。(4)通过12周的肌力康复训练后,对比女性老年人干预前后的血液指标,表现为:干预后女性老年人胰岛素样生长因子-1(IGF-1)无显著性差异(P0.05),干预后女性老年人肌肉生长抑制素(MSTN)、肿瘤坏死因子α(TNF-α)均显著低于干预前(P0.01,P0.05),干预后女性老年人超氧化物歧化酶(SOD)显著高于干预前(P0.05)。结论:(1)肌力康复训练对男性老年人的衰老性肌萎缩的身体机能指标握力和四米步速影响明显,对骨骼肌质量指数SMI诊断指标诊断影响不明显,表现为干预后握力增加,四米步速上升,但骨骼肌质量指数SMI则没有显著性变化。对男性老年人的衰老性肌萎缩血清指标中MSTN、SOD、TNF-α影响明显,对血清指标IGF-1影响不明显,表现为干预后MSTN、TNF-α指标下降,SOD指标上升,而IGF-1指标则没有显著性变化。(2)肌力康复训练对女性老年人的衰老性肌萎缩的身体机能指标握力和四米步速影响明显,对骨骼肌质量指数SMI诊断指标诊断影响不明显,表现为干预后握力增加,四米步速上升,但骨骼肌质量指数SMI则没有显著性变化。对女性老年人的衰老性肌萎缩血清指标中MSTN、SOD、TNF-α影响明显,对血清指标IGF-1影响不明显,表现为干预后MSTN、TNF-α指标下降,SOD指标上升,而IGF-1指标则没有显著性变化。
[Abstract]:Objective aging muscle atrophy not only refers to the decline in skeletal muscle mass, but also the gradual decline in muscle function, the decline of strength, the decrease of the maximum contraction speed and the widespread slow contraction and relaxation. In the background of the aging of the population in China, the aging related diseases are growing more and more, among them aging sex The in-depth study and treatment of muscular atrophy have become a potential threat, and more and more attention will be paid. However, it is still a problem to be solved to select the appropriate intervention scheme to prevent aging muscle atrophy. Therefore, it is of great significance to study the practical training program for the intervention of the elderly. In this study, 15 elderly people with aging myatrophy were selected from the elderly hospital of Ziyang Lake in Wuhan, including 8 men and 7 women. Based on the standards issued by the EWGSOP (European seniors aging muscle atrophy research team), the body function test and biochemical blood indexes were collected, and the physical function indexes included: Grip strength (men's "f30kg, women" f20kg), skeletal muscle mass (men's "f10.76 kg/m2, women" f6.76kg/m2) and 4 meter gait (male / female "F1 m/s), biochemical blood indicators include: superoxide dismutase (SOD), insulin growth factor -1 (IGF-1), myostatin (MSTN), tumor necrosis factor alpha (TNF- alpha). Through 12 weeks of muscle strength rehabilitation training, To compare the effect of muscle strength rehabilitation training on the body function index and biochemical blood indexes of senescent amyotrophic patients and lay the foundation for the formulation of scientific and reasonable exercise program for senile amyotrophic patients. Results: (1) after 12 weeks of muscle strength rehabilitation training, the physical function indexes before and after the intervention of male elderly people were compared. The grip strength of the male elderly was significantly higher than that before the intervention (P0.01), and the four meter gait of the male elderly was significantly higher than that before the intervention (P0.01), while the skeletal muscle mass index (SMI) of the male elderly was not significantly different from that before the intervention (P0.05). (2) after 12 weeks of muscle rehabilitation training, the blood indexes before and after the intervention of the male elderly were compared. There was no significant difference between the male elderly and the insulin-like growth factor -1 (IGF-1) after the dry prognosis (P0.05). The prognosis of the male elderly with myostatin (MSTN) and tumor necrosis factor alpha (TNF- alpha) were significantly lower than that before intervention (P0.01, P0.05) after the dry prognosis (P0.01, P0.05). After intervention, the superoxide dismutase (SOD) of male elderly was significantly higher than that before intervention (P0.01). (3) through the intervention (3) After 12 weeks of muscle rehabilitation training, the index of body function before and after the intervention of the female elderly was compared. The grip strength of the female elderly was significantly higher than that before the intervention (P0.01), and the four meter gait of the female elderly was significantly higher than that before the intervention (P0.01), while the skeletal muscle mass index (SMI) of the female elderly was not significant before the intervention. Difference (P0.05). (4) after 12 weeks of muscle strength rehabilitation training, the blood indexes before and after the intervention of female elderly were compared. There was no significant difference (P0.05) in the female elderly patients with insulin like growth factor (IGF-1) after the intervention (P0.05), and the prognosis of the female elderly with myostatin (MSTN) and the tumor necrosis factor alpha (TNF- alpha) were significantly lower than those before the intervention. (P0.01, P0.05), the prognosis of female elderly patients with superoxide dismutase (SOD) was significantly higher than that before the intervention (P0.05). Conclusion: (1) the effect of muscle strength rehabilitation training on the body function index of aging myatrophy and four meter speed is obviously affected, and the diagnosis of skeletal muscle mass index SMI is not significantly affected, and it is the post intervention grip. The strength increased at four meters, but there was no significant change in the skeletal muscle mass index SMI. The effect of MSTN, SOD, TNF- alpha on the serum index of aging myatrophy in male elderly was obvious, and the effect on serum index IGF-1 was not obvious, and the prognosis was MSTN, TNF- a index decreased, SOD index increased, but the IGF-1 index had no significant change. (2) The effect of muscle strength rehabilitation training on the body function index of aging muscle atrophy of female elderly was obvious, and the influence on the diagnosis index of skeletal muscle mass index SMI was not obvious, which showed the increase of grip strength and four meter pace, but the skeletal muscle mass index SMI had no significant change. The effect of MSTN, SOD, TNF- alpha in the serum index of aging muscle atrophy was obvious, and the effect on serum index IGF-1 was not obvious, which showed that the prognosis was MSTN, TNF- alpha index decreased, SOD index increased, but IGF-1 index had no significant change.
【学位授予单位】：武汉体育学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：G804.2

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