用于糖尿病并发症研究的极低频脉冲磁场设计与实现

发布时间：2018-01-19 18:56

本文关键词： 脉冲磁场 STM 糖尿病螺线管线圈　出处：《电工电能新技术》2017年12期 　论文类型：期刊论文

【摘要】：糖尿病作为一种终身代谢性疾病,并发症高达一百多种。研究表明,脉冲磁场能促进胶原纤维沉积,改善胶原纤维排列和取向,有助于糖尿病伤口愈合,能有效地促进糖尿病患者的溃疡静脉愈合。为了进一步探索脉冲磁场在糖尿病治疗中的场强、脉冲宽度、频率和治疗时间,本文提出了一种脉冲磁场发生方案,应用此方案设计了基于STM32单片机控制的低频脉冲磁场发生装置,其可以输出0~100Hz连续可调,最大磁感应强度100m T的脉冲磁场。利用ANSYS软件进行仿真,确定并优化磁场产生线圈的结构与尺寸。用STM32单片机对磁场进行控制,设计出相应的硬件及其接口,实现了对磁感应强度的实时控制与检测。通过选择开关器件、设计线圈和续流回路等措施减少脉冲磁场宽度,通过对螺线管线圈结构的设计,减少线圈发热对生物实验的影响。试验表明,该装置操作简便,性能稳定可靠,已在糖尿病并发症治疗的研究中得到应用。
[Abstract]:As a lifelong metabolic disease, diabetes has more than 100 complications. Studies show that pulsed magnetic field can promote collagen fiber deposition, improve the arrangement and orientation of collagen fibers, and contribute to the healing of diabetic wounds. In order to further explore the field intensity, pulse width, frequency and treatment time of pulsed magnetic field in the treatment of diabetes mellitus, a pulse magnetic field generation scheme is proposed in this paper. The low frequency pulse magnetic field generator controlled by STM32 single chip computer is designed with this scheme, which can output 0 ~ 100Hz continuously adjustable. The maximum magnetic induction intensity is 100m T pulse magnetic field. The structure and size of magnetic field generator coil are determined and optimized by ANSYS software. The magnetic field is controlled by STM32 single chip microcomputer. The corresponding hardware and its interface are designed to realize the real-time control and detection of the magnetic induction intensity, and the pulse magnetic field width is reduced by selecting the switch device, designing the coil and the continuous current loop and so on. Through the design of solenoid coil structure, the effect of coil fever on biological experiment is reduced. The experiment shows that the device is easy to operate, stable and reliable, and has been applied in the treatment of diabetic complications.
【作者单位】：生物电磁学北京市重点实验室中国科学院电工研究所;中国科学院大学;
【基金】：国家自然科学基金项目(31670855)
【分类号】：TM15
【正文快照】： 1引言脉冲磁场(Pulsed Electromagnetic Field,PEMF)在生物医学中的应用受到广泛关注,过去几十年国内外研究人员做了大量的基础和临床研究。研究发现PEMF对促进骨骼和软骨组织损伤愈合[1]、调节微循环有显著的生物学效应[2,3];对糖代谢、脂代谢和缓解疼痛等均有显著治疗效果[4

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