液膜技术处理低浓度6-氨基青霉烷酸溶液的研究

发布时间：2018-06-02 21:27

本文选题：6-氨基青霉烷酸 + 液膜技术　；参考：《天津大学》2015年硕士论文

【摘要】：6-氨基青霉烷酸,简称6-APA,是合成各种半合成青霉素类药物的重要中间体,具有广泛的应用和广阔的市场。6-APA工业上主要由生物酶法合成,其具有反应条件温和、转化率高、污染少等诸多优点。6-APA的分离提纯主要选用结晶工艺,而结晶母液中会有少量的6-APA残留。这种低浓度的6-APA溶液直接排放不仅造成了资源浪费,同时提高了环保处理费用。由此,本文研究了应用液膜技术来处理低浓度的6-APA溶液,以实现的工业废液中6-APA的高效回收。首先,以6-APA稀溶液为研究对象,通过实验研究了厚体液膜络合萃取回收6-APA的传质过程,确定了厚体液膜络合萃取过程实验条件下的较优条件,并对厚体液膜络合萃取动力学进行了研究。结果表明:取得实验条件下最佳萃取效果时原料相的pH为6.2左右;混合有机萃取剂中载体甲基三辛基氯化铵的较优浓度为0.70 mol/L;混合萃取剂:原料相:反萃相=0.8:1:1(体积比);反萃相的较佳pH为1.5左右;反萃相为KCl的盐溶液,氯离子较优浓度为1mol/L。其次,应用反萃相预分散式中空纤维支撑液膜(HFSLM-SD)萃取技术来处理低浓度6-APA溶液的过程。通过实验研究确定了实验条件下下HFSLM-SD的较优条件。结果表明:反萃相搅拌速率最佳为300rpm;较优的管程原料相流量150ml/min;壳程反萃相流量选择125ml/min;实验适宜的跨膜压差为6psi。通过4次连续实验对液膜稳定性进行了研究,说明了本实验中支撑液膜的连续性操作和支撑液膜的液膜稳定性都具有良好的效果。最后,通过对HFSLM-SD萃取6-APA的过程进行传质分析,对传质过程进行了合理假设,并在此基础上建立了总传质系数模型。得到稳态下进料侧、膜内、反萃侧传质系数和总传质系数分别为得到得到kw=3.51×10-6 m/s,km=1.81×10-6m/s,ks=6.52×10-6 m/s,总传质系数K=1.18×10-6 m/s,说明中空纤维膜络合萃取6-APA的传质过程中的阻力主要集中在跨膜传质过程中;通过对比实验过程中原料相6-APA浓度随时间变化,验证了模型的准确性。本文运用液膜技术耦合络合萃取对低浓度6-APA溶液的处理进行了实验研究,取得了一定效果,可为其他学者在低浓度6-APA的处理工艺研究以及液膜技术的应用研究提供一定借鉴。
[Abstract]:6-aminopenicillanic acid, or 6-APA, is an important intermediate for the synthesis of various semi-synthetic penicillin drugs. It is widely used and widely marked.6-APA is mainly synthesized by biological enzyme method in industry, and its reaction conditions are mild and the conversion rate is high. The separation and purification of 6-APA, such as less pollution and so on, mainly use crystallization process, and there will be a small amount of 6-APA residue in the crystallization mother liquor. The direct discharge of this low concentration of 6-APA solution not only results in waste of resources, but also increases the cost of environmental protection treatment. Therefore, the application of liquid membrane technology to the treatment of low concentration of 6-APA solution was studied in order to realize the efficient recovery of 6-APA from industrial waste liquor. Firstly, the mass transfer process of 6-APA recovery by thick humoral membrane complexation extraction was studied by using 6-APA dilute solution as the research object, and the optimum conditions were determined under the experimental conditions. The complex extraction kinetics of thick humoral membrane was studied. The results show that the pH of the raw material phase is about 6.2 when the optimum extraction effect is obtained under the experimental conditions. The optimum concentration of methyl trioctyl ammonium chloride in the mixed organic extractant is 0.70 mol / L, and the optimum concentration of mixed extractant is 0.8: 1: 1: 1 (volume ratio); the optimum pH of the stripping phase is about 1.5; the optimum concentration of chlorine ion is 1 / mol / L in the salt solution of KCl and the optimum concentration of chlorine ion is 1 / mol / L. Secondly, the extraction process of low concentration 6-APA solution was studied by using the stripping phase predispersive hollow fiber supporting liquid membrane HFSLM-SD extraction technology. The optimal conditions of HFSLM-SD under experimental conditions were determined by experimental study. The results show that the optimum stirring rate of stripping phase is 300rpm, the optimal flow rate of raw material phase is 150ml / min, the flow rate of shell stripping phase is 125ml / min, and the suitable pressure difference is 6psi. The stability of liquid film was studied through four continuous experiments. The results show that the continuous operation of supporting liquid membrane and the stability of liquid film of supporting liquid membrane have good effect in this experiment. Finally, through the mass transfer analysis of HFSLM-SD extraction of 6-APA, the reasonable assumption of mass transfer process is made, and the model of total mass transfer coefficient is established. The mass transfer coefficient and total mass transfer coefficient of feed side, inside membrane and back extraction side were obtained as follows: kw=3.51 脳 10-6 m / s / s = 1.81 脳 10 ~ (-6) m / s / s, total mass transfer coefficient K ~ (-1) = 1.18 脳 10 ~ (-6) m / s, respectively, indicating that the resistance in the process of mass transfer in 6-APA extraction by hollow fiber membrane complexation was mainly concentrated in the process of transmembrane mass transfer. The accuracy of the model was verified by comparing the 6-APA concentration of raw material phase with time. In this paper, the treatment of low concentration 6-APA solution with liquid membrane technique coupled with complex extraction has been studied experimentally, and some results have been obtained, which can be used for reference by other scholars in the treatment process of low concentration 6-APA and the application research of liquid membrane technology.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：X787;TQ028.8

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