雾霾颗粒物在真实人体上呼吸道中的沉积特性研究
发布时间：2018-12-06 20:14
【摘要】：雾霾颗粒物进入人身体后,会严重威胁人类的健康和生命,而呼吸道是雾霾颗粒物致病的主要通道。了解气流在人体呼吸道内的流动情况及可吸入颗粒物在其中的沉积规律,可以帮助人们认识呼吸道疾病的致病机理、找到治疗呼吸道疾病的方法,而且可以对一些喷发式深入气管类药物的研究开发具有指导意义。本文基于真实人体上呼吸道模型,研究了呼吸道内气流的流动情况以及雾霾颗粒物在其中的沉积特征,主要进行了以下几方面的研究工作:1、应用真实人体医学CT原始数据,进行了鼻腔上呼吸道至会厌部位的三维重构,精确塑造了整个上呼吸道结构。2、采用大涡模拟方法,计算计算了三种呼吸强度下,即Q=15 L/min(静坐),30 L/min(轻微运动),60L/min(剧烈运动)非稳态呼吸时上呼吸道内部的流场,分析了各特征部位及整个上呼吸道的气流运动情况。3、基于拉格朗日方法,模拟了三种呼吸强度下不同颗粒物粒径,即d=0.5μm,1μm,2.5μm,5μm,10μm颗粒物在呼吸道内部的运动和沉积。统计了不同粒径段颗粒物在呼吸道各部位的局部沉积率、整体沉积率以及逃逸率。总结出可吸入颗粒物在上呼吸道内部的沉积规律。4、对较大粒径的颗粒进行气固双向耦合模拟,分析对比沉积率的不同之处。
[Abstract]:The entry of haze particles into human body will seriously threaten human health and life, and respiratory tract is the main pathogenicity channel of haze particles. Understanding the flow of airflow in the body's respiratory tract and the deposition of respirable particles in it can help people understand the pathogenic mechanism of respiratory diseases and find ways to treat them. It can also be used for the research and development of some eruptive-type tracheobronchial drugs. Based on the model of real human upper respiratory tract, the flow of airflow in the respiratory tract and the deposition characteristics of haze particles in it were studied in this paper. The main works were as follows: 1. The raw data of real human medical CT were used. Three-dimensional reconstruction of the upper respiratory tract to the epiglottic part of the nasal cavity was carried out, and the entire structure of the upper respiratory tract was accurately molded. 2. By using the large eddy simulation method, three breathing intensities, Q15 L/min, were calculated. The flow field inside the upper respiratory tract during 30 L/min (slight exercise) and 60L/min (intense exercise) unsteady breathing is analyzed. 3 based on the Lagrangian method, the airflow movement of each characteristic part and the whole upper respiratory tract is analyzed. The movement and deposition of particles with different particle sizes (0.5 渭 m) and 2.5 渭 m (2.5 渭 m) and 10 渭 m (10 渭 m) in respiratory tract were simulated. The local deposition rate, overall deposition rate and escape rate of particles with different particle sizes in various parts of respiratory tract were calculated. The deposition rules of inhalable particles in upper respiratory tract were summarized. 4. The gas-solid bidirectional coupling simulation of larger particle size was carried out to analyze and compare the differences of deposition rate.
【学位授予单位】：中国计量大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R56;X513
本文编号：2366596
[Abstract]:The entry of haze particles into human body will seriously threaten human health and life, and respiratory tract is the main pathogenicity channel of haze particles. Understanding the flow of airflow in the body's respiratory tract and the deposition of respirable particles in it can help people understand the pathogenic mechanism of respiratory diseases and find ways to treat them. It can also be used for the research and development of some eruptive-type tracheobronchial drugs. Based on the model of real human upper respiratory tract, the flow of airflow in the respiratory tract and the deposition characteristics of haze particles in it were studied in this paper. The main works were as follows: 1. The raw data of real human medical CT were used. Three-dimensional reconstruction of the upper respiratory tract to the epiglottic part of the nasal cavity was carried out, and the entire structure of the upper respiratory tract was accurately molded. 2. By using the large eddy simulation method, three breathing intensities, Q15 L/min, were calculated. The flow field inside the upper respiratory tract during 30 L/min (slight exercise) and 60L/min (intense exercise) unsteady breathing is analyzed. 3 based on the Lagrangian method, the airflow movement of each characteristic part and the whole upper respiratory tract is analyzed. The movement and deposition of particles with different particle sizes (0.5 渭 m) and 2.5 渭 m (2.5 渭 m) and 10 渭 m (10 渭 m) in respiratory tract were simulated. The local deposition rate, overall deposition rate and escape rate of particles with different particle sizes in various parts of respiratory tract were calculated. The deposition rules of inhalable particles in upper respiratory tract were summarized. 4. The gas-solid bidirectional coupling simulation of larger particle size was carried out to analyze and compare the differences of deposition rate.
【学位授予单位】：中国计量大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R56;X513
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