基于FPGA的嵌入式药物导入仪的研究

发布时间：2018-06-28 12:13

本文选题：电致孔法 + 药物导入仪　；参考：《西北大学》2012年硕士论文

【摘要】：电致孔技术是透皮给药的一种方法,经过长达20多年的发展,已经形成了一门成熟的学科。电致孔技术与其它透皮给药技术相比,因其具有给药简单、效率高、电参数易控制等优点,在细胞生物工程、基因工程和临床医学试验等领域得到了广泛的应用。由于电致孔导入药物的分子类型、导入效率及效果与导入仪器的电参数有直接关系,本论文设计了一种用于电致孔技术研究的脉冲幅度、宽度和间隔宽范围可调的药物导入仪。论文首先介绍了电致孔技术的相关知识,讨论了药物导入仪的电参数对电致孔给药效果的影响因素,对照分析了现有药物导入仪的优缺点,并根据目前电致孔技术的发展提出了本设计的电参数要求。通过方案论证提出了一种基于FPGA的嵌入式药物导入仪设计方案。其次重点介绍了FPGA控制电路、程控放大电路和脉冲功率放大电路的设计原理及系统构成。设计中发挥逻辑电路速度快、C语言处理数据能力强的优点,采用数字化SOPC解决方案在FPGA中嵌入Nios II软核处理器实现系统的控制；采用硬件描述语言在FPGA中设计并构建了基于直接频率合成技术的脉冲信号发生器,实现了系统的结构设计和装配调试。通过对本系统的仿真和测试,证明了系统方案的可行性。本文所设计的药物导入仪具有参数调整范围宽、体积小、维护方便、易于升级、性价比高等优点。
[Abstract]:Electroporation technology is a method of transdermal drug delivery. After more than 20 years of development, it has formed a mature subject. Compared with other transdermal drug delivery technology, electroporation technology has the advantages of simple drug delivery, high efficiency and easy control of electrical parameters. It has been obtained in the field of cell biological engineering, gene engineering and clinical medicine. Extensive application. Due to the molecular types of electroporate introduction of drugs, the efficiency and effect of introduction are directly related to the electrical parameters of the imported instrument. In this paper, a kind of drug importing instrument, which is used in the study of electroporing technology, is designed for the adjustable pulse amplitude, width and interval wide range.
This paper first introduces the related knowledge of electroporing technology, discusses the influence factors of the electrical parameters of the drug importing instrument on the effect of the electroporer, compares the advantages and disadvantages of the existing drug importing instrument, and puts forward the demand for the electric parameters according to the development of the current electroporing technology. A kind of FPGA based on the scheme demonstration is put forward. Design of embedded drug introduction instrument.
Secondly, the design principle and system composition of FPGA control circuit, program control amplifier circuit and pulse power amplifying circuit are introduced. In the design, the advantages of fast logic circuit and strong data ability in C language are used in the design. The digital SOPC solution is embedded in FPGA with Nios II soft core processor to realize the control of the system; and the hardware drawing is used. The language has designed and constructed a pulse signal generator based on direct frequency synthesis technology in FPGA, and realized the structural design, assembly and debugging of the system.
Through the simulation and test of this system, the feasibility of the system scheme is proved. The drug importing instrument designed in this paper has the advantages of wide range of parameters adjustment, small volume, convenient maintenance, easy to upgrade and high cost performance.
【学位授予单位】：西北大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R197.39;TP368.1

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