超声电导治疗仪的设计与实现

发布时间：2019-03-03 19:48

【摘要】：近年来,随着医药领域的飞速发展,病人在给药的方式上也有了更多的选择。然而,传统的给药方式如口服、注射由于存在某种程度上自身的缺点,已经无法满足病人们对于某些特定药物的给药需求。透皮给药系统(TDS)作为一种经皮肤表面给药的用药途径,能够使人体局部或全身都得到治疗。因此,研究这种给药途径对未来病人病情的治疗具有非常重要的理论与工程意义。鉴于皮肤角质层的阻碍作用,人们需要通过物理和化学的方法才能辅助大多数难以渗透皮下的药物渗入。虽然电致孔法、离子导入法和超声波法都可以作为新的经皮吸收方法,但是有研究发现这三种方法单独作用时,某些特定药物的渗透效果并不明显。本文针对以上三种方法单独作用时不能满足某些药物渗透率的问题,结合透皮给药仪器现有的发展技术和需求,设计研究了集电致孔、现代离子导入和超声空化技术为一体的超声电导治疗仪。该治疗仪是以增强型8051单片机STC90C58RD+为核心控制部件,外扩电致孔模块、电导模块、超声模块、电极异常检测模块、人机交互模块和身份识别卡接口模块等。另外,通过自制的读写器,完成了身份识别卡对治疗仪的相关控制功能,给治疗仪在无人监控下的管理工作带来方便。本论文背景基于作者在南京某公司实习时参与的超声电导治疗仪的研制,研究成果经过全方位的调试过程已顺利通过了国家相关部门的检测,但是对于一个透皮给药领域,还有很多工作有待进一步的研究和推广。
[Abstract]:In recent years, with the rapid development of medicine, patients also have more choices in the way of drug delivery. However, traditional administration methods such as oral administration, injection due to some of its own shortcomings, has been unable to meet the needs of patients for certain drugs. Transdermal drug delivery system (TDS), as a drug delivery route through the skin surface, can be treated locally or all over the body. Therefore, it is of great theoretical and engineering significance to study this route of administration for the treatment of patients' condition in the future. In view of the blocking effect of the cuticle of the skin, physical and chemical methods are needed to assist the infiltration of most drugs that are difficult to penetrate under the skin. Although electroporation, iontophoresis and ultrasound can all be used as new percutaneous absorption methods, it has been found that when these three methods act alone, the permeation effect of some specific drugs is not obvious. In view of the problem that the above three methods can not satisfy the permeability of some drugs when they act alone, this paper designs and studies the electroporation, which is based on the current development technology and demand of the transdermal drug delivery apparatus. Modern iontophoresis and ultrasonic cavitation technology as one of the ultrasonic conductivity therapeutic apparatus. The therapeutic instrument is based on the enhanced 8051 single chip microcomputer STC90C58RD as the core control unit, external expansion of the hole module, conductivity module, ultrasonic module, electrode anomaly detection module, human-computer interaction module and identity card interface module. In addition, through the self-made reader and writer, the related control function of the identification card to the therapeutic instrument is completed, which brings convenience to the management of the therapeutic instrument under the control of no one. The background of this thesis is based on the development of the ultrasonic conductivity therapy instrument which the author participated in during his internship in a company in Nanjing. The research results have passed the examination of the relevant departments of the state successfully after the omni-directional debugging process, but for a transdermal drug delivery field, There is still a lot of work to be further studied and promoted.
【学位授予单位】：南京理工大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：TP368.12

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