过氧化物酶体增殖物激活受体γ基因多态性与肺炎脓毒症临床转归的相关性研究

发布时间：2018-01-22 22:22

本文关键词： 脓毒症过氧化物酶体增殖物激活受体γ 单核苷酸多态性临床转归　出处：《医学研究生学报》2017年12期 　论文类型：期刊论文

【摘要】：目的过氧化物酶体增殖物激活受体γ(PPARγ)作为核转录因子能通过多种机制发挥抗炎作用。文中拟在华东汉族人中探讨PPARγ基因多态性与脓毒症临床转归的相关性。方法收集2014年2月至2015年2月南京总医院呼吸科收治的由肺部感染导致的脓毒症患者194例。以改良的多重连接酶检测反应技术对PPARγ基因中13个常见的单核苷酸多态性位点进行基因分型。非条件Logistic回归分析,校正年龄、性别、吸烟/饮酒状态、APACHE II评分等后,在不同遗传模式下分析各位点基因型与脓毒症临床转归(脓毒性休克/器官功能障碍/死亡)的相关性。结果 rs1801282 GC+GG较CC能降低重度器官功能障碍风险[OR(95%CI)=0.11(0.01~0.95),P=0.022];rs2920502 GG较CC+CG死亡风险降低[OR(95%CI)=0.22(0.04~0.99),P=0.043]。结论 PPARγ基因遗传多态性可能与肺炎脓毒症多器官功能障碍和死亡相关;但并未发现变异与脓毒性休克相关。
[Abstract]:Objective peroxisome proliferator-activated receptor (PPAR 纬). As a nuclear transcription factor, PPAR 纬 gene polymorphism and clinical outcome of sepsis were studied in the Han nationality of East China. Methods from February 2014 to 20, the study was conducted to investigate the relationship between the polymorphism of PPAR 纬 gene and the clinical outcome of sepsis. In February, 15 years, 194 patients with sepsis caused by pulmonary infection were admitted to Department of Respiratory, Nanjing General Hospital. 13 common single nucleotide polymorphisms in PPAR 纬 gene were detected by modified multiple ligase assay technique. Sex loci were genotyped. Non conditional Logistic regression analysis was performed. After adjusting for age, sex, smoking / drinking status, Apache II score and so on. Analysis of genotypes and clinical outcome of sepsis (septic shock / organ dysfunction / death) under different genetic patterns. Results rs1801282 GC GG decreased the risk of severe organ dysfunction compared with CC. [ORS2920502 GG reduced the risk of death compared with CC CG. [ORY95CII 0.22 / 0. 04 / 0.99). Conclusion the genetic polymorphism of PPAR 纬 gene may be associated with multiple organ dysfunction and death in pneumonia sepsis. However, no mutation was found to be associated with septic shock.
【作者单位】：南京军区南京总医院保健科;南京军区南京总医院干部病房二科;
【基金】：国家自然科学基金(81701890) 全军保健专项科研课题(13BJZ11)
【分类号】：R459.7
【正文快照】： 作者单位:210002南京,南京军区南京总医院保健科(朱小蔚),干部病房二科(黄方、方放、郭蕾、万文辉、刘瑜)0引言脓毒症是机体对入侵的致病微生物产生广泛、失控的炎症反应而导致的一种复杂的临床综合征[1-3]。脓毒症及其严重并发症,即脓毒性休克、多器官功能障碍综合征(multipl

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