去甲肾上腺素转运体T182C基因多态性与抑郁症发病关联性的Meta分析

发布时间：2018-01-25 00:01

本文关键词： 去甲肾上腺素转运体 TC 多态性抑郁症 Meta分析　出处：《重庆医科大学学报》2017年10期 　论文类型：期刊论文

【摘要】：目的:采用Meta分析探讨去甲肾上腺素转运体(norepinephrine transporter,NET)T182C基因多态性与抑郁症易感性之间的关系。方法:通过检索Pub Med、Embase、万方数据库、维普中文科技期刊数据库、中国知网(Chinese National Knowledge Infrastructure,CNKI)数据库,获取相关研究,提取有效数据后,采用STATA 12.0进行统计分析。评价指标采用比值比(odds ratio,OR)、95%可信区间(confidence interval,CI)与P值,计算4种不同遗传模型下T182C基因多态性与抑郁症发病风险的关联性。结果:共检索出12篇符合标准的文献进入Meta分析,包括病例组3 056例,对照组2 861例。在等位(OR=1.15,95%CI=1.04~1.28,P=0.009)、共显性(OR=1.41,95%CI=1.04~1.90,P=0.026)、隐性(OR=1.44,95%CI=1.13~1.85,P=0.004)3种遗传模式下T182C位点多态性与抑郁症易感性的关系具有统计学意义,且等位基因C或基因型CC增加抑郁症发病风险。亚组分析发现采用不同的评价量表是异质性的主要来源。结论:NET T182C基因多态性与抑郁症的发生有关,等位基因C是导致抑郁症发生的一个潜在危险因素。
[Abstract]:Objective: to investigate the norepinephrine transporter, a norepinephrine transporter, by Meta analysis. The relationship between NET)T182C gene polymorphism and susceptibility to depression. Methods: to search the database of Pub Medbase, Wanfang database and Weipu Chinese science and technology journal. The Chinese National Knowledge Infrastructure (CNKI) database is used to obtain relevant research. After extracting valid data, STATA 12.0 was used for statistical analysis. 95% confidence interval confidence intervalescence) and P value. The association of T182C gene polymorphisms with the risk of depression was calculated under four different genetic models. Results: a total of 12 articles were retrieved for Meta analysis. There were 3 056 cases in the case group and 2 861 cases in the control group. Co-dominant OR1. 41 and 95% CI1. 04 + 1. 90 P0. 026, recessive OR1. 4 4 + 95% CI1. 131. 85. The relationship between the polymorphism of T182C locus and the susceptibility to depression was statistically significant. Allele C or genotype CC increased the risk of depression. Subgroup analysis showed that different evaluation scales were the main source of heterogeneity. Conclusion: net. The polymorphism of T182C gene is associated with the occurrence of depression. Allele C is a potential risk factor for depression.
【作者单位】：川北医学院基础医学院生物化学教研室;川北医学院影像系;
【基金】：四川省教育厅项目基金资助项目(编号:09ZA040)
【分类号】：R749.4
【正文快照】： 抑郁症是精神科的常见疾病之一,其发病机制至今未明,但普遍认为遗传因素与抑郁症的发生发展密切相关。研究表明,去甲肾上腺素(norepinephrine,NE)主要参与觉醒、情感、意识、食欲、性欲等生理功能,在抑郁症的发病中可能起着重要作用。NE是通过NET的微调而发挥不同作用的:去甲

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