范可尼贫血基因在卵泡发育中的调节作用

发布时间：2018-02-09 10:45

本文关键词： 范可尼贫血基因卵泡发育同源重组修复细胞分裂　出处：《遗传》2017年06期 　论文类型：期刊论文

【摘要】：范可尼贫血(Fanconi anemia,FA)是一种罕见的常染色体或X染色体连锁的隐性遗传病,其发生源于范可尼贫血基因(FA基因)突变。FA基因是一组在DNA交联损伤中起同源重组修复作用的基因。FA女性患者常见早发性卵巢功能衰退(premature ovarian insufficient,POI)的特征,而FA小鼠也表现出生殖细胞严重缺乏,这些结果提示FA基因在哺乳动物卵泡发育中起重要作用。研究显示FA基因在促进原始生殖细胞增生,维持正常卵母细胞减数分裂,参与卵泡发育的促性腺激素调节以及卵母细胞与颗粒细胞生长过程中的相互调节等方面调节卵泡发育。本文综述了FA基因在卵泡发育中的作用和分子机制方面的研究进展,为POI的病因学解析提供遗传基础。
[Abstract]:Fanconi AnemiaFa) is a rare recessive disorder linked to autosomes or X chromosomes. The gene is a group of genes that play a role in homologous recombination repair in DNA crosslinking injury. FA gene is a common feature of premature ovarian function decline and premature ovarian in posi in female patients with DNA crosslinking injury. These results suggest that FA gene plays an important role in mammalian follicle development. Studies have shown that FA gene promotes the proliferation of primordial germ cells and maintains meiosis of normal oocytes. The regulation of gonadotropins involved in follicular development and the interaction between oocytes and granulosa cells are involved in follicular development. In this review, the role of FA gene in follicular development and its molecular mechanism are reviewed. To provide genetic basis for etiological analysis of POI.
【作者单位】：中南大学湘雅二医院;
【基金】：湖南省科技计划项目(编号:2015SK20212)资助~~
【分类号】：R556

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