SH2B1基因多态性与妊娠糖尿病的相关性研究

发布时间：2018-02-14 21:07

本文关键词： 妊娠糖尿病 SHB基因多态性胰岛素抵抗　出处：《中国现代医学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨SH2B1基因多态性与妊娠糖尿病患者胰岛素抵抗的关系。方法选取164例妊娠期糖尿病(GDM)患者和130例糖耐量正常孕妇。采用限制性片段多态性聚合酶链反应检测SH2B1基因型,并且分析相关临床资料。结果 GDM组SH2B1(rs4788102)基因GA型与GG型比较,差异有统计学意义[OR=1.531,(95%CI:1.093,2.374)P=0.04],A等位基因频率与G等位基因频率比较,差异有统计学意义[OR=1.436,(95%CI:1.091,1.972)P=0.01]。GDM组GA+AA基因型与GG基因型比较,差异有统计学意义[OR=1.699,(95%CI:1.185,2.479)P=0.02]。GDM组中GA+AA基因型体重指数、三酰甘油、瘦素及稳态模型评估胰岛素抵抗指数与GG基因型比较,差异有统计学意义(P0.05)。经Logistic回归分析显示,GA+AA基因型为稳态模型法测定胰岛素抵抗指数升高的危险因素。结论 SH2B1(rs4788102)基因多态性可能是GDM的一个易感位点,监测孕妇该基因位点,可以用于GDM发生风险的预测。
[Abstract]:Objective to investigate the relationship between SH2B1 gene polymorphism and insulin resistance in patients with gestational diabetes mellitus (GDM). Methods SH2B1 genotypes were detected by restriction fragment polymorphism polymerase chain reaction (PCR) in 164 patients with gestational diabetes mellitus (GDM) and 130 pregnant women with normal glucose tolerance. Results there was a significant difference between GA genotype and GG genotype of SH2B1R rs4788102) gene in GDM group. The difference between GA AA genotype and GG genotype in GDM group was statistically significant [OR1. 531C: 1.0932.374P0. 04] and G allele frequency were significantly higher than those in GDM group [OR1. 436CIV: 1.091 / 1.972P0. 01] the difference of GA AA genotype and GG genotype in GDM group was statistically significant (P < 0. 05), and there was a significant difference between GG genotype and GA AA genotype in GDM group (P < 0. 01), and there was no significant difference between GG genotype and GA AA genotype in GDM group (P < 0. 01). There was a significant difference in body mass index (BMI) of GA AA genotype, triacylglycerol, leptin and steady-state model in GDM group. The insulin resistance index of GDM group was compared with that of GG genotype. Logistic regression analysis showed that GA-AA genotype was a risk factor for the determination of insulin resistance index by steady-state model method. Conclusion SH2B1 rs4788102) gene polymorphism may be a susceptible site for GDM. It can be used to predict the risk of GDM.
【作者单位】：河南大学淮河医院妇产科;
【分类号】：R714.256

【相似文献】