血管内皮生长因子Rs3025039基因多态性与脑卒中关联研究的Meta分析

发布时间：2018-02-14 23:35

  本文关键词： 血管内皮生长因子 基因多态性 脑卒中 Meta分析　出处：《中风与神经疾病杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的系统评价血管内皮生长因子(vascular endothelial growth factor,VEGF)Rs3025039基因多态性与脑卒中关联性。方法检索Pub Med、EMbase、Wed of Science、The Cochrane Library、Elsevier、中国知网、中国生物医学文献数据库、万方数据库、维普数据库和中国科技论文在线中关于VEGF Rs3025039基因多态性与脑卒中关系研究,对纳入研究进行方法学质量评价,采用Rev Man 5.3软件进行Meta分析。结果共纳入11项研究,其中10项研究均为亚洲人群。包括病例3597例,对照2748例。分析结果显示:(1)VEGF Rs3025039 T/C等位基因、TT/CC基因型、遗传显性模式和隐性模式的合并OR值以及95%CI分别是1.25(1.15~1.37)、1.38(1.08~1.76)、1.26(1.03~1.54)和1.33(1.06~1.68),均P0.05;(2)杂合基因型CT相对于CC的合并OR值及95%CI为1.12(0.86~1.46),P=0.40;(3)在显性模式下,脑梗死组纳入7项研究(OR=1.31,95%CI 1.01~1.70),脑出血组纳入3项研究(OR=1.09,95%CI 0.68~1.73),大动脉粥样硬化型组纳入3项研究(OR=1.36,95%CI 0.74~2.51),小动脉闭塞型组纳入4项研究(OR=1.25,95%CI 0.90~1.73),均P0.05。结论 VEGF Rs3025039 T位点多态性可能增加脑卒中风险,特别在中国等亚洲人群中。
[Abstract]:Objective to systematically evaluate the association between the polymorphism of vascular endothelial growth factor (VEGFN) Rs3025039 gene and stroke. Methods to search Pub Medbase of Science of the Cochrane Library Elsevier, Chinese Biomedical Literature Database and Wanfang Database. The relationship between the polymorphism of VEGF Rs3025039 gene and stroke was studied in Weip database and Chinese scientific and technological papers online. The methodological quality of inclusion study was evaluated, and Meta analysis was carried out by Rev Man 5.3 software. The results were included in 11 studies. Ten of the studies were all Asian people, including 3 597 cases and 2 748 controls. The results of analysis showed that the T / C allele of VEGF-VEGF-T / C was expressed as TT- / CC genotype. The combined OR value and 95 CI of genetic dominant pattern and recessive pattern were 1.25 / 1.15 / 1.37 / 1.381.08 / 1.76 / 1.261.26 / 1.031.54 / 1.331.331061.68 / 1, respectively, respectively. The combined OR value and 95CI of heterozygous genotype CT versus CC were 1.120.861.46 / 1.46 / 0.40 / 3) in dominant mode, respectively. Seven studies were included in the cerebral infarction group, one hundred and thirty-one 95 CI 1.01a 1.70, three studies OR1.0995 CI 0.681.73, three studies OR1.36 95 CI 0.742.51in the cerebral infarction group, and four studies in the small artery occlusion group, all P0.05.Conclusion the polymorphism of VEGF Rs3025039 T locus can be used in all of the four studies (OR1.25995 CI 0.90,1.73). Conclusion the polymorphism of VEGF Rs3025039 T loci can be used in all of the four studies. Conclusion the polymorphism of VEGF Rs3025039 T loci can be used in all of the four studies (OR1.2595 / 95 CI 0.90 / 1.73). Conclusion the polymorphism of VEGF Rs3025039 T loci can be used in all of the three studies. Can increase the risk of stroke, Especially among Asian people such as China.
【作者单位】： 暨南大学附属第一医院神经内科和脑血管病中心;暨南大学附属第一医院消化内科;
【基金】：国家自然科学基金(No.81171084) 广东省自然科学基金(No.2014A030313384) 广东省医学科研基金(No.A2014381) 广州市科技计划(No.2014Y2-00505、201508020004)
【分类号】：R743.3
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