亚甲基四氢叶酸还原酶基因多态性与甲氨蝶呤治疗类风湿关节炎疗效和安全性的Meta分析

发布时间：2018-02-15 02:53

本文关键词： 亚甲基四氢叶酸还原酶基因多态性甲氨蝶呤类风湿关节炎　出处：《中国临床药理学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的系统评价中国人群亚甲基四氢叶酸还原酶(MTHFR)基因多态性与甲氨蝶呤(MTX)治疗类风湿关节炎的临床疗效和药物不良反应的关联性。方法检索中国知网(CNKI)、维普、万方、中国生物医学文献、Pub Med、Em Base及Cochrane Library等数据库,收集中国人群MTHFR C677T及A1298C基因多态性与甲氨蝶呤治疗类风湿关节炎临床疗效和药物不良反应的病例对照研究,用Rev Man5.3软件进行Meta分析。结果共纳入5篇文献,449例患者,其中MTHFR C677T5篇,A1298C3篇。结果显示,MTHFR A1298C AA疗效低于MTHFR A1298C AC/CC(P0.05);MTHFR C677T CC药物不良反应发生率低于MTHFR C677T CT/TT(P0.05)。结论在中国人群中,MTHFR C677T及A1298C基因多态性可能影响甲氨蝶呤治疗类风湿关节炎的临床疗效和药物不良反应。但由于纳入研究的数量有限,将来仍需在更大的类风湿关节炎人群中做进一步的研究。
[Abstract]:Objective to systematically evaluate the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with methotrexate MTX (MTX) in the treatment of rheumatoid arthritis (RA). The Chinese biomedical literature including Pub Meden Em Base and Cochrane Library were used to collect the polymorphism of MTHFR C677T and A1298C gene, and the clinical efficacy and adverse drug reactions of methotrexate in the treatment of rheumatoid arthritis. Meta analysis was carried out with Rev Man5.3 software. Results 449 patients were included in 5 literatures. The results showed that the efficacy of MTHFR A1298C AA was lower than that of MTHFR A1298C / A1298CAA. The incidence of adverse drug reactions of MTHFR C677T CC was lower than that of MTHFR C677T CTR / TTT P0.050.Conclusion MTHFR C677T and A1298C gene polymorphisms may affect methotrexate treatment of rheumatoid joints in Chinese population. Clinical efficacy and adverse drug reactions. However, due to the limited number of studies included, Further research is needed in the larger population of rheumatoid arthritis.
【作者单位】：北京大学人民医院药剂科;
【分类号】：R593.22

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