LAMA3基因在肿瘤中研究新进展

发布时间：2018-02-26 15:15

本文关键词： LAMA DNA甲基化肿瘤黏着斑侵袭转移　出处：《中国肿瘤生物治疗杂志》2017年06期 　论文类型：期刊论文

【摘要】：肿瘤的发生发展是一个受多因素影响的逐步发展的过程,其中全基因组低甲基化和局部性高甲基化是肿瘤产生的重要原因。LAMA3基因作为层黏连蛋白的编码基因,被证实参与肿瘤的发生发展。基因启动子区的高甲基化往往使得LAMA3低表达甚至沉默,miRNA与RNA可变剪接等表观遗传修饰也调控肿瘤细胞中LAMA3的表达。LAMA3的异常表达还与黏着斑和细胞外基质-受体两条信号通路密切相关,从而影响肿瘤细胞的侵袭和转移。本文就LAMA3在肿瘤发生发展过程中的作用及其在肿瘤中异常表达与表观遗传学的关系作一综述。
[Abstract]:Tumorigenesis and development is a progressive process affected by many factors, in which genomic hypomethylation and local hypermethylation are important causes of tumorigenesis. LAMA3 gene is the encoding gene of laminin. Hypermethylation of the promoter region of the gene often causes low expression of LAMA3 and even silencing epigenetic modifications such as mRNAs and variable splicing of RNA to regulate the abnormal expression of LAMA3 in tumor cells. Adhesion plaque and extracellular matrix receptor signaling pathway are closely related, The role of LAMA3 in tumorigenesis and development and the relationship between abnormal expression and epigenetics in tumor were reviewed.
【作者单位】：广西医科大学附属肿瘤医院妇瘤科暨区域性高发肿瘤早期防治研究教育部重点实验室;
【基金】：国家自然科学基金资助项目(No.81572579,No.81660430) 广西科学研究与技术开发计划课题资助项目(No.14124004) 广西自然科学基金资助项目(No.2014jjA A40637)~~
【分类号】：R730.2

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