中国汉族血液病患者CYP2C19基因多态性对伏立康唑初始稳态谷浓度的影响

发布时间：2018-03-01 11:49

本文关键词： 伏立康唑 CYPC 治疗药物监测个体化用药　出处：《中国临床药理学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的研究CYP2C19基因多态性及生理病理等临床非遗传因素对伏立康唑在中国汉族血液病患者体内初始稳态血浆谷浓度[(C_(ss))_(min)]的影响。方法采用高效液相色谱法(HPLC)检测患者体内(C_(ss))_(min),飞行时间质谱法(MALDI-TOF MS)对rs4244285、rs498689和rs12248560三个位点进行基因检测。采用非参数检验、Spearman秩相关检验及多重线性回归等统计学方法研究CYP2C19基因多态性及临床非遗传因素对(C_(ss))_(min)的影响。结果共纳入了78名患者,(C_(ss))_(min)变异系数达64.9%。CYP2C19基因多态性、年龄是造成(C_(ss))_(min)个体间差异的影响因素,其中中间代谢型(IMs)及弱代谢型(PMs)患者较快代谢型(EMs)患者表现出更高的(C_(ss))_(min),IMs及PMs患者之间的(C_(ss))_(min)差异无统计学意义(P0.05);年龄与(C_(ss))_(min)呈正相关。结论本研究为早期制定VRC个体化给药方案提供了临床依据,以达到提高VRC抗真菌疗效和促进患者预后的目的。
[Abstract]:Objective to study the effect of clinical non-genetic factors such as polymorphism of CYP2C19 gene and physiological and pathological factors on the initial steady-state plasma valley concentration of Volconazole in patients with hematological diseases of Han nationality in China. Methods High performance liquid chromatography (HPLC) was used to detect the initial steady-state plasma valley concentration in patients with hematologic diseases. The three loci of rs4244285- rs498689 and rs12248560 were detected by MALDI-TOF MS. Nonparametric tests were used to study the polymorphism of CYP2C19 gene and the clinical non-genetic factors by using non-parametric test, Spearman rank correlation test and multiple linear regression. Results A total of 78 patients were included in this study. The coefficient of variation (CV) was 64.9%. CYP2C19 gene polymorphism, Age is the factor that causes the difference between individuals. The patients with intermediate metabolic type (IMs) and weak metabolic type (PMs) showed a higher incidence of rapid metabolic type (EMsM). (conclusion this study has no significant difference between PMs patients and patients with PMs. There is no significant difference between them (P0.05); age is positively correlated with Csssubtix. Conclusion this study is a good method for the early development of VRC individuals in this study. [WT5 "HZ] [WT5" HZ] [WT5 "HZ] [WT5" HZ] [WT5BZ] there is no significant difference between the patients with IMs and the patients with PMs. The chemotherapy regimen provides the clinical basis. In order to improve the antifungal effect of VRC and promote the prognosis of patients.
【作者单位】：郑州大学人民医院/河南省人民医院药学部;郑州大学人民医院/河南省人民医院血液科;
【基金】：河南省科技攻关基金资助项目(152102310134);河南省科技攻关基金资助项目(162102310287)
【分类号】：R969

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