CYP17基因多态性和环境暴露因素交互作用与前列腺癌易感性的关系

发布时间：2018-03-01 16:05

本文关键词： CYP基因多态性前列腺肿瘤环境因素　出处：《中国老年学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨CYP17基因多态性和环境因素暴露交互作用与前列腺易感性的关系。方法采用病例对照设计,采集128例病例和128例对照的血样,应用聚合酶链-限制性片段长度多态性(PCR-RELP)技术检测外周血细胞色素P450家族17(CYP17)基因型。采用Logistic回归模型进行多因素分析。结果与对照组相比,饮酒30年以上、吸烟30年以上、饮食中猪肉摄入较多、遗精年龄早于16岁、首次性生活年龄早、35岁以前每周性生活次数多、肿瘤家族史是前列腺癌的危险因素,而经常吃水果、喝绿茶、卷心菜摄入较多是保护因素。基因CYP17的A2/A2多态突变型能够增加前列腺癌发生风险(OR=2.63,95%CI值:1.37~3.58),且有剂量效应梯度。CYP17基因多态性与首次遗精年龄和家族史因素间存在交互作用。结论 CYP基因多态性、环境相关因素暴露及其交互作用与前列腺癌有相关性。
[Abstract]:Objective to investigate the relationship between CYP17 gene polymorphism and exposure interaction between environmental factors and prostate susceptibility. Methods Blood samples of 128 cases and 128 controls were collected by case-control design. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP) technique was used to detect the cytochrome P450 family 17 (CYP17) genotypes in peripheral blood. Multivariate analysis was carried out using Logistic regression model. The results showed that compared with the control group, drinking alcohol for more than 30 years, smoking for more than 30 years, and smoking for more than 30 years were observed. More pork was consumed in the diet, the spermatozoa was older than 16 years old, the first sexual life age was earlier than 35 years old, the cancer family history was the risk factor of prostate cancer, and often ate fruit and drank green tea. The higher intake of cabbage is the protective factor. The A2 / A2 polymorphism of CYP17 gene can increase the risk of prostate cancer. There is a dose effect gradient. The polymorphism of CYP17 gene interacts with the age of first spermatozoa and family history factors. Conclusion Polymorphism of CYP gene, Exposure to environmental related factors and their interactions were associated with prostate cancer.
【作者单位】：右江民族医学院附属医院泌尿外科;
【基金】：2014年广西自然科学基金项目(2014GXNSFBA118154)
【分类号】：R737.25

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