p53基因codon72多态性与亚洲人群前列腺癌发病风险的Meta分析

发布时间：2018-03-02 16:35

本文选题：前列腺肿瘤　切入点：p基因　出处：《重庆医学》2017年25期 　论文类型：期刊论文

【摘要】：目的利用Meta分析的方法系统评价p53基因codon72多态性与亚洲人群前列腺癌发病风险的关系。方法检索PubMed、Medline、Ovid、万方和CNKI数据库,筛查p53基因codon72多态性位点与亚洲人群前列腺癌易感性关联的病例-对照研究。采用Stata 12.0软件对获得的各项研究数据进行统计分析,并评估数据的可靠性和统计文献的发表偏倚等。结果 Meta分析显示,p53基因codon72多态性与亚洲人群前列腺癌发病风险无明显相关性。对对照组来源进行亚组分析结果显示,基于医院来源的亚组,codon72多态性在P vs.A[OR=0.680,95%CI(0.546,0.847),P=0.001]、PP vs.AA[OR=0.409,95%CI(0.260,0.645),P=0.000]、PA+PP vs.AA[OR=0.513,95%CI(0.350,0.749),P=0.001]等模型中均能显著降低亚洲人群的前列腺癌易感性。然而,在对照组来源基于普通人群的亚组中,codon72多态性位点在PAvs.AA[OR=1.664,95%CI(1.272,2.177),P=0.000]和PA+PP vs.AA[OR=1.314,95%CI(1.020,1.693),P=0.003 6]的基因型中却增加了亚洲人群前列腺癌发生的危险性。根据是否符合HWE平衡进行了亚组分析,结果发现,在不符合HWE平衡的亚组中,p53基因codon72多态性在PP vs.AA[OR=0.251,95%CI(0.135,0.467),P=0.000]和PA+PP vs.AA[OR=0.564,95%CI(0.330,0.964),P=0.036]的基因型中是降低亚洲人群前列腺癌易感性的一个保护因素。结论 p53基因codon72多态性与亚洲人群前列腺癌易感性无关。
[Abstract]:Objective to systematically evaluate the relationship between p53 gene codon72 polymorphism and the risk of prostate cancer in Asian population by Meta analysis. Methods PubMedMedline Ovid, Wanfang and CNKI databases were searched. A case-control study on the association of p53 gene codon72 polymorphism with the susceptibility to prostate cancer in Asian population. The data obtained were statistically analyzed by Stata 12.0 software. Results Meta analysis showed that there was no significant correlation between p53 gene codon72 polymorphism and the risk of prostate cancer in Asian population. The polymorphisms of codon72 in subgroup based on hospital origin can significantly reduce the susceptibility to prostate cancer in the models of P vs.A [OR0.680C95CII 0.5460.47P0. 001] PP vs.AA [OR0.40995 CIQ 0.2600.2645 P0.000] PA PP vs.AA [OR0.51395CI0.350 0.749P0.001]. However, there was no significant difference in the risk of prostate cancer in Asian population. The polymorphisms of codon72 locus in the subgroup of the control group based on the general population increased the risk of prostate cancer in Asian population according to the subgroup analysis of PAvs.AA [OR1. 664 / 95CII 1.272 / 2.177] and PA PP vs.AA [OR1. 31495 / CI1.020 / 1.693P0. 0036]. A subgroup analysis was carried out according to the HWE balance. The p53 gene codon72 polymorphism was a protective factor in the genotypes of PP vs.AA (ORR 0.255) and PA PP vs.AA (OR0.56495) and PA PP vs.AA (0.3300.964). Conclusion p53 gene codon72 polymorphism is not associated with the susceptibility of Asian population to prostate cancer. [conclusion] there is no correlation between p53 gene codon72 polymorphism and the susceptibility of Asian population to prostate cancer. [conclusion] there is no relationship between p53 gene codon72 polymorphism and the susceptibility of Asian population to prostate cancer.
【作者单位】：吉林医药学院附属医院泌尿外科;
【分类号】：R737.25

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